MMR vaccination induces trained immunity via functional and metabolic reprogramming of γδ T cells.

Autor:	Röring RJ; Department of Internal Medicine and Radboud Center for Infectious Diseases and.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Debisarun PA; Department of Internal Medicine and Radboud Center for Infectious Diseases and.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Botey-Bataller J; Department of Internal Medicine and Radboud Center for Infectious Diseases and.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine (CiiM) and.; TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany., Suen TK; Department of Immunology and Metabolism, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Bulut Ö; Department of Internal Medicine and Radboud Center for Infectious Diseases and.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Kilic G; Department of Internal Medicine and Radboud Center for Infectious Diseases and.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Koeken VA; Department of Internal Medicine and Radboud Center for Infectious Diseases and.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine (CiiM) and.; TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany., Sarlea A; Department of Internal Medicine and Radboud Center for Infectious Diseases and., Bahrar H; Department of Internal Medicine and Radboud Center for Infectious Diseases and.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Dijkstra H; Department of Internal Medicine and Radboud Center for Infectious Diseases and.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Lemmers H; Department of Internal Medicine and Radboud Center for Infectious Diseases and.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Gössling KL; Department for Pediatric Oncology, Hematology and Clinical Immunology and., Rüchel N; Department for Pediatric Oncology, Hematology and Clinical Immunology and., Ostermann PN; Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich Heine University Duesseldorf, Dusseldorf, Germany., Müller L; Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich Heine University Duesseldorf, Dusseldorf, Germany., Schaal H; Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich Heine University Duesseldorf, Dusseldorf, Germany., Adams O; Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich Heine University Duesseldorf, Dusseldorf, Germany., Borkhardt A; Department for Pediatric Oncology, Hematology and Clinical Immunology and., Ariyurek Y; Leiden Genome Technology Center, Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands., de Meijer EJ; Leiden Genome Technology Center, Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands., Kloet SL; Leiden Genome Technology Center, Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands., Ten Oever J; Department of Internal Medicine and Radboud Center for Infectious Diseases and.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Placek K; TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany., Li Y; Department of Internal Medicine and Radboud Center for Infectious Diseases and.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine (CiiM) and.; TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany., Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases and.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Immunology and Metabolism, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Jazyk:	angličtina
Zdroj:	The Journal of clinical investigation [J Clin Invest] 2024 Jan 30; Vol. 134 (7). Date of Electronic Publication: 2024 Jan 30.
DOI:	10.1172/JCI170848
Abstrakt:	The measles, mumps, and rubella (MMR) vaccine protects against all-cause mortality in children, but the immunological mechanisms mediating these effects are poorly known. We systematically investigated whether MMR can induce long-term functional changes in innate immune cells, a process termed trained immunity, that could at least partially mediate this heterologous protection. In a randomized, placebo-controlled trial, 39 healthy adults received either the MMR vaccine or a placebo. Using single-cell RNA-Seq, we found that MMR caused transcriptomic changes in CD14+ monocytes and NK cells, but most profoundly in γδ T cells. Monocyte function was not altered by MMR vaccination. In contrast, the function of γδ T cells was markedly enhanced by MMR vaccination, with higher production of TNF and IFN-γ, as well as upregulation of cellular metabolic pathways. In conclusion, we describe a trained immunity program characterized by modulation of γδ T cell function induced by MMR vaccination.
Databáze:	MEDLINE
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