Practical guidance for direct oral anticoagulant use in the treatment of venous thromboembolism in primary and metastatic brain tumor patients.

Autor: Ranjan S; Department of Neurology, Cleveland Clinic Florida, Weston, Florida, USA., Leung D; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Ghiaseddin AP; Department of Neurosurgery, University of Florida, Gainesville, Florida, USA., Taylor JW; Department of Neurology, University of California, San Francisco, California, USA., Lobbous M; Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Dhawan A; Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Budhu JA; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Coffee E; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Melnick K; Department of Neurosurgery, University of Florida, Gainesville, Florida, USA., Chowdhary SA; Tampa General Hospital Cancer Institute, Tampa General Hospital, Tampa, Florida, USA., Lu-Emerson C; Department of Neurology, Maine Medical Center and Maine Health Cancer Care, Portland, Maine, USA., Kurz SC; Department of Neurology & Interdisciplinary Neuro-Oncology, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Tübingen, Germany., Burke JE; Department of Neurology, Beth Israel Lahey Health, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA., Lam K; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Patel MP; Preston Robert Tisch Brain Tumor Center, Duke University, Durham, North Carolina, USA., Dunbar EM; Piedmont Brain Tumor Center, Atlanta, Georgia, USA., Mohile NA; Department of Neurology, University of Rochester, Rochester, New York, USA., Peters KB; Preston Robert Tisch Brain Tumor Center, Duke University, Durham, North Carolina, USA.
Jazyk: angličtina
Zdroj: Cancer [Cancer] 2024 May 01; Vol. 130 (9), pp. 1577-1589. Date of Electronic Publication: 2024 Jan 30.
DOI: 10.1002/cncr.35220
Abstrakt: Management of venous thromboembolism (VTE) in patients with primary and metastatic brain tumors (BT) is challenging because of the risk of intracranial hemorrhage (ICH). There are no prospective clinical trials evaluating safety and efficacy of direct oral anticoagulants (DOACs), specifically in patients with BT, but they are widely used for VTE in this population. A group of neuro-oncology experts convened to provide practical clinical guidance for the off-label use of DOACs in treating VTE in patients with BT. We searched PubMed for the following terms: BTs, glioma, glioblastoma (GBM), brain metastasis, VTE, heparin, low-molecular-weight heparin (LWMH), DOACs, and ICH. Although prospective clinical trials are needed, the recommendations presented aim to assist clinicians in making informed decisions regarding DOACs for VTE in patients with BT.
(© 2024 American Cancer Society.)
Databáze: MEDLINE
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