A triple combination of latanoprost, fractional CO 2 laser, and platelet-rich plasma in localized vitiligo: A clinical and histopathologic study.

Autor: Omar SS; Department of Dermatology, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Elmulla KF; Department of Dermatology, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Aly RG; Department of Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Elkaffas A; Alexandria Police Hospital, Alexandria, Egypt., Ismail A; Department of Dermatology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Jazyk: angličtina
Zdroj: Photodermatology, photoimmunology & photomedicine [Photodermatol Photoimmunol Photomed] 2024 Jan; Vol. 40 (1), pp. e12944.
DOI: 10.1111/phpp.12944
Abstrakt: Background: Several treatment modalities are available for the treatment of vitiligo due to the lack of a uniformly effective therapy. Topical latanoprost 0.005% is an effective topical treatment. Fractional CO 2 laser alone or combined with platelet-rich plasma (PRP) has been proposed as effective adjunctive therapies.
Objectives: We aimed to compare the efficacy of topical latanoprost 0.005% (Ioprost®, Orchidia, Egypt) combined with either add-on fractional CO 2 laser or fractional CO 2 -PRP versus topical latanoprost monotherapy in the treatment of localized stable vitiligo.
Patients/methods: The study included 60 patients randomly assigned into three equal groups. Group A patients received topical latanoprost drops only. Group B patients received topical latanoprost drops and fractional CO 2 laser sessions at 2-week interval for 3 months. Group C patients received topical latanoprost drops and fractional CO 2 laser sessions combined with PRP at a 2-week interval for 3 months. The mean improvement score by the physician was calculated 4 months after the start of the study. Punch skin biopsies were obtained before treatment and 4 months from the beginning of the study and stained with H&E and HMB-45 antibody for evaluation of pigmentation.
Results: Significant clinical improvement of vitiligo lesions with significant increase of re-pigmentation were reported in the three treated groups. Latanoprost in combination with fractional CO 2 and PRP was associated with more significant therapeutic outcomes than either combined latanoprost and fractional CO 2 or latanoprost alone.
Conclusion: Fractional CO 2 laser-PRP enhances the therapeutic efficacy of latanoprost 0.005% in the treatment of localized stable vitiligo.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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