Evaluating the effectiveness of the Charlson Comorbidity Index in predicting immune checkpoint inhibitor-related adverse events.

Autor: Onur İD; Health Sciences University, Dr Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Department of Medical Oncology, Ankara, 06200, Turkey., Mutlu E; Department of Medical Oncology, Erciyes University Faculty of Medicine, Kayseri, 38039, Turkey., Sertesen E; Health Sciences University, Dr Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Department of Medical Oncology, Ankara, 06200, Turkey., Önder T; Health Sciences University, Dr Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Department of Medical Oncology, Ankara, 06200, Turkey., Duran AO; Health Sciences University, Dr Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Department of Medical Oncology, Ankara, 06200, Turkey., İnanç M; Department of Medical Oncology, Erciyes University Faculty of Medicine, Kayseri, 38039, Turkey.
Jazyk: angličtina
Zdroj: Immunotherapy [Immunotherapy] 2024 Mar; Vol. 16 (5), pp. 295-303. Date of Electronic Publication: 2024 Jan 30.
DOI: 10.2217/imt-2023-0270
Abstrakt: Aims: Our study aimed to evaluate the effectiveness of the Charlson Comorbidity Index (CCI) in predicting immune-related adverse events (irAEs) in solid tumor patients receiving immunotherapy. Patients & methods/materials: The CCI score at the time of initiation of immunotherapy was calculated in 164 solid tumor patients receiving immunotherapy and the correlation between the CCI score and immune toxicity was evaluated. Results: A significant relationship was found between CCI score and irAEs in lung cancer and renal cell cancer patients. In malignant melanoma, no significant relationship was found between the CCI score and the occurrence of irAEs. Conclusion: We argue that CCI can be used to predict irAEs, but we believe that a specific comorbidity index that includes autoimmune diseases should be developed.
Databáze: MEDLINE
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