Disruptive consequences of monosodium glutamate on male reproductive function: A review.

Autor:	Oluwole DT; Department of Physiology, College of Health Sciences, Crescent University, Abeokuta, Ogun State, Nigeria.; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria., Ebiwonjumi OS; Department of Physiology, College of Health Sciences, Crescent University, Abeokuta, Ogun State, Nigeria., Ajayi LO; Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Anchor Biomed Research Institute, Ogbomoso, Oyo State, Nigeria., Alabi OD; Department of Nutrition and Dietetics, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria., Amos V; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Anchor Biomed Research Institute, Ogbomoso, Oyo State, Nigeria., Akanbi G; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Anchor Biomed Research Institute, Ogbomoso, Oyo State, Nigeria., Adeyemi WJ; Department of Physiology, Adeleke University, Ede, Osun State, Nigeria., Ajayi AF; Department of Physiology, College of Health Sciences, Crescent University, Abeokuta, Ogun State, Nigeria.; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Department of Physiology, Adeleke University, Ede, Osun State, Nigeria.; Anchor Biomed Research Institute, Ogbomoso, Oyo State, Nigeria.
Jazyk:	angličtina
Zdroj:	Current research in toxicology [Curr Res Toxicol] 2024 Jan 09; Vol. 6, pp. 100148. Date of Electronic Publication: 2024 Jan 09 (Print Publication: 2024).
DOI:	10.1016/j.crtox.2024.100148
Abstrakt:	Monosodium glutamate (MSG) is one of the most extensively used flavour enhancers worldwide. Although it is widely regarded as a safe food additive with no recommended daily dosage, its over-consumption has been associated with notably pathophysiological events in various tissues and organs of the body. Previous studies have reported of the neuro- cardio- and hepato- toxic effects of its excessive exposure. Moreover, the food additive instigates metabolic dysfunction. It has been established that MSG damages male reproductive accessory organs like prostate glands and epididymis. In addition, it impairs serum enzymatic activities and serum levels of testosterone, gonadotropin-releasing hormone, luteinizing hormone and cholesterol. Reduced sperm count, sperm motility, sperm morphology, and sperm viability, imbalances in male reproductive hormones, alongside alteration in the histoarchitecture of the testes and other male reproductive tissues have also been connected with excessive exposure to MSG. Literature reports affirm the link between the over-consumption of MSG and reproductive organ weight and male sexual behaviour. This review article addresses the multi-systemic effects of exposure to MSG and the possible mechanism of action of the compound with a focus on the negative implications of the food additive on male reproductive functions and the possible role of natural antioxidants in male reproductive functions. carefully selected keywords were used during the literature search to gather credible and up-to-date information about the subject matter. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 Published by Elsevier B.V.)
Databáze:	MEDLINE
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