Puerarin Attenuates Cycloheximide-Induced Oxidative Damage and Memory-Consolidation Impairment in Rats.
| Autor: | Wu KJ; School of Pharmacy, China Medical University, 40402 Taichung, Taiwan., Lien JC; School of Pharmacy, China Medical University, 40402 Taichung, Taiwan., Wu CR; The Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, 40402 Taichung, Taiwan. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of integrative neuroscience [J Integr Neurosci] 2024 Jan 16; Vol. 23 (1), pp. 17. |
| DOI: | 10.31083/j.jin2301017 |
| Abstrakt: | Background: Cycloheximide (CXM), an antifungal antibiotic, causes impaired memory consolidation as a side effect partially by disturbing the activities of the central catecholaminergic and cholinergic system. Some reports indicated that puerarin prevented memory impairment in various models in rodents. However, the protective effects of puerarin on the side effects of cycloheximide for memory consolidation impairment have not yet been investigated. Methods: The protective effects of puerarin on CXM-induced memory-consolidation impairment, and memory impairment produced by central administration of AF64A neurotoxin, were investigated using a passive avoidance task in rats. A combination of transmitter receptor agonists and antagonists was used to explore the effects of puerarin on nervous system function. The activity of antioxidant defense systems and neurotransmitter systems in the prefrontal cortex and hippocampus were assayed. Results: Systemic (25 and 50 mg/kg, i.p.) or central (5 and 10 µg/brain, i.c.v.) administration of puerarin attenuated CXM-induced memory-consolidation impairment produced by 1.5 mg/kg CXM (s.c.) in rats. The improvements produced by 50 mg/kg puerarin were blocked by cholinergic antagonists, a 5-HT2 receptor agonist, and an adrenergic receptor antagonist. Puerarin (only at 50 mg/kg, i.p.) reversed the CXM-induced alterations of the levels of norepinephrine in the prefrontal cortex and the levels of monoamines in the hippocampus. Puerarin also increased antioxidant-defense-system activities in the prefrontal cortex and hippocampus, which had been decreased by CXM. Conclusions: We suggested that the attenuating effects of puerarin on CXM-induced memory-consolidation impairment may be due to decrease oxidative damage and the normalition of the neurotransmitter function in the prefrontal cortex and hippocampus. Competing Interests: The authors declare no conflict of interest. Chi-Rei Wu is serving as one of the Editorial Board members of this journal. We declare that Chi-Rei Wu had no involvement in the peer review of this article and has no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to Gernot Riedel. (© 2024 The Author(s). Published by IMR Press.) |
| Databáze: | MEDLINE |
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