Epigenetics of Ageing and Psychiatric Disorders.

Autor:	Colită CI; Doctoral School, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania., Udristoiu I; Department of Psychiatry, University of Medicine and Pharmacy, 200349 Craiova, Romania., Ancuta DL; Cantacuzino National Medico-Military Institute for Research and Development, 050096 Bucharest, Romania., Hermann DM; Doctoral School, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania.; Chair of Vascular Neurology, Dementia and Ageing, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany., Colita D; Doctoral School, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania., Colita E; Doctoral School, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania., Glavan D; Department of Psychiatry, University of Medicine and Pharmacy, 200349 Craiova, Romania., Popa-Wagner A; Department of Psychiatry, University of Medicine and Pharmacy, 200349 Craiova, Romania.; Chair of Vascular Neurology, Dementia and Ageing, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
Jazyk:	angličtina
Zdroj:	Journal of integrative neuroscience [J Integr Neurosci] 2024 Jan 16; Vol. 23 (1), pp. 13.
DOI:	10.31083/j.jin2301013
Abstrakt:	Both classic epigenetic modifications and microRNAs can impact a range of bodily processes, from metabolism to brain function, and may contribute to the development of diseases such as cancer, cardiovascular disorders, and psychiatric disorders. Numerous studies suggest a connection between epigenetic changes and mood disorders. In this study, we performed a comprehensive search using PubMed and Google for the terms "epigenetics", "ageing", "miRNA", "schizophrenia", and "mood disorders" in the titles and abstracts of articles. Epigenetic changes during early life may play a crucial role in triggering severe mental disorders and shaping their clinical trajectory. Although these alterations can take place at any age, their impact may not be immediately evident or observable until later in life. Epigenetic modifications play a crucial role in the ageing process and challenge the prevailing belief that mutations are the primary driver of ageing. However, it is plausible that these epigenetic changes are a consequence of the disorder rather than its root cause. Moreover, both the disorder and the epigenetic alterations may be influenced by shared environmental or genetic factors. In the near future, we might be able to replace chronological age with biological age, based on the epigenetic clock, with the promise of providing greater therapeutic benefits. A wide range of epigenetic drugs are currently under development at various stages. Although their full effectiveness is yet to be realized, they show great potential in the treatment of cancer, psychiatric disorders, and other complex diseases. Competing Interests: The authors declare no conflict of interest. Aurel Popa-Wagner is serving as one of the Guest editors of this journal. We declare that Aurel Popa-Wagner had no involvement in the peer review of this article and has no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to Gernot Riedel. (© 2024 The Author(s). Published by IMR Press.)
Databáze:	MEDLINE
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