Correlation between impulse oscillometry with bronchodilator reversibility in asthmatic population in a tertiary referral centre.

Autor: Mas Fazlin MJ; Universiti Kebangsaan Malaysia, Faculty of Medicine, Respiratory Unit, Kuala Lumpur, Malaysia., Ching ZH; Universiti Kebangsaan Malaysia, Faculty of Medicine, Respiratory Unit, Kuala Lumpur, Malaysia., Azat AA; Universiti Kebangsaan Malaysia, Faculty of Medicine, Respiratory Unit, Kuala Lumpur, Malaysia., Mohamed Faisal AH; Universiti Kebangsaan Malaysia, Faculty of Medicine, Respiratory Unit, Kuala Lumpur, Malaysia. faisal.hamid@ppukm.ukm.edu.my.
Jazyk: angličtina
Zdroj: The Medical journal of Malaysia [Med J Malaysia] 2024 Jan; Vol. 79 (1), pp. 21-27.
Abstrakt: Introduction: Spirometry is considered as a 'gold standard' for diagnosis of asthma. Impulse oscillometry (IOS) is an alternative diagnostic tool which requires less cooperation by the participants. We performed a study to determine the correlation of IOS with bronchodilator reversibility from spirometry in asthmatic participants. We studied the correlation between forced expiratory flow (FEF 25%-75% ) and differences between the resistance at 5Hz and 20Hz (R 5 -R 20 ) in small airway disease (SAD) and the proportion of SAD diagnosed using IOS.
Materials and Methods: This was a cross-sectional study involving 82 asthmatic participants in Hospital Canselor Tuanku Muhriz (HCTM), Universiti Kebangsaan Malaysia (UKM) conducted between December 2020 till January 2022. Participants performed pre- and post-bronchodilator IOS and spirometry within the same day. Correlation between spirometry and IOS parameters and FEF 25%-75% with IOS were determined and analysed.
Results: The change of forced expiratory volume in 1 second (FEV1) was statistically correlated with a change of R5 in IOS. A decrement of 14.5% in R5 can be correlated with positive bronchodilator response (BDR) with a sensitivity of 63.9% and specificity of 60.9%, p=0.007. Pre-bronchodilator FEF 25%-75% correlated with all parameters of SAD in IOS, e.g., R 5 -R 20 , reactance at 5Hz (X5) and area of reactance (AX), p < 0.05. IOS detection for SAD is higher compared to FEF 25%-75% in the BDR negative group (91.3% vs 58.7%).
Conclusion: IOS detected both bronchodilator reversibility and SAD hence can be considered as an alternative tool to spirometry for diagnosis of asthma in adults. IOS detected SAD more than FEF 25%-75% , especially in BDR-negative group.
Databáze: MEDLINE
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