Identifying cortical structure markers of resilience to adversity in young people using surface-based morphometry.

Autor:	Cornwell H; Department of Psychology, University of Bath, 10 West, Claverton Down, Bath, Somerset BA2 7AY, UK., Toschi N; Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', Facoltà di Medicina e Chirurgia, Viale Montpellier, Rome 1 - 00133, Italy.; Martinos Center for Biomedical Imaging and Harvard Medical School, 149 13th Street Charlestown, Boston, MA 02129, USA., Hamilton-Giachritsis C; Department of Psychology, University of Bath, 10 West, Claverton Down, Bath, Somerset BA2 7AY, UK., Staginnus M; Department of Psychology, University of Bath, 10 West, Claverton Down, Bath, Somerset BA2 7AY, UK., Smaragdi A; Child Development Institute, 197 Euclid Ave., Toronto, Ontario, M6J 2J8, Canada., Gonzalez-Madruga K; Department of Psychology, Middlesex University, The Burroughs, Hendon, London NW4 4BT, UK., Mackes N; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK., Rogers J; Centre for Human Brain Health, School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Martinelli A; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Deutschordenstrasse 50, Frankfurt am Main 60528, Germany.; Fresenius University of Applied Sciences, School of Psychology, Marienburgstrasse 6, Frankfurt am Main 60528, Germany., Kohls G; Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany.; Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Fetscherstrasse 74, Dresden 01307, Germany., Raschle NM; Department of Child and Adolescent Psychiatry, University of Basel, Psychiatric University Hospital, Wilhelm Klein-Strasse 27, Basel 4002, Switzerland.; Jacobs Center for Productive Youth Development at the University of Zurich, Andreasstrasse 15, Zurich 8050, Switzerland., Konrad K; Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany.; JARA-Brain Institute II, Molecular Neuroscience and Neuroimaging, RWTH Aachen and Research Centre Juelich, Wilhelm-Johnen-Straße, Juelich 52425, Germany., Stadler C; Department of Child and Adolescent Psychiatry, University of Basel, Psychiatric University Hospital, Wilhelm Klein-Strasse 27, Basel 4002, Switzerland., Freitag CM; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Deutschordenstrasse 50, Frankfurt am Main 60528, Germany., De Brito SA; Centre for Human Brain Health, School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Fairchild G; Department of Psychology, University of Bath, 10 West, Claverton Down, Bath, Somerset BA2 7AY, UK.
Jazyk:	angličtina
Zdroj:	Social cognitive and affective neuroscience [Soc Cogn Affect Neurosci] 2024 Feb 07; Vol. 19 (1).
DOI:	10.1093/scan/nsae006
Abstrakt:	Previous research on the neurobiological bases of resilience in youth has largely used categorical definitions of resilience and voxel-based morphometry methods that assess gray matter volume. However, it is important to consider brain structure more broadly as different cortical properties have distinct developmental trajectories. To address these limitations, we used surface-based morphometry and data-driven, continuous resilience scores to examine associations between resilience and cortical structure. Structural MRI data from 286 youths (Mage = 13.6 years, 51% female) who took part in the European multi-site FemNAT-CD study were pre-processed and analyzed using surface-based morphometry. Continuous resilience scores were derived for each participant based on adversity exposure and levels of psychopathology using the residual regression method. Vertex-wise analyses assessed for correlations between resilience scores and cortical thickness, surface area, gyrification and volume. Resilience scores were positively associated with right lateral occipital surface area and right superior frontal gyrification and negatively correlated with left inferior temporal surface area. Moreover, sex-by-resilience interactions were observed for gyrification in frontal and temporal regions. Our findings extend previous research by revealing that resilience is related to surface area and gyrification in frontal, occipital and temporal regions that are implicated in emotion regulation and face or object recognition. (© The Author(s) 2024. Published by Oxford University Press.)
Databáze:	MEDLINE
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