CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.
Autor: | Scherlinger M; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. marc.scherlinger@chru-strasbourg.fr.; Rheumatology department, Strasbourg University Hospital of Hautepierre, Strasbourg, France. marc.scherlinger@chru-strasbourg.fr.; Laboratoire d'ImmunoRhumatologie Moléculaire, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_S 1109, Strasbourg, France. marc.scherlinger@chru-strasbourg.fr., Li H; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Pan W; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Li W; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Karino K; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Vichos T; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Boulougoura A; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Yoshida N; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Tsokos MG; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Tsokos GC; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. gtsokos@bidmc.harvard.edu. |
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Jazyk: | angličtina |
Zdroj: | Nature communications [Nat Commun] 2024 Jan 29; Vol. 15 (1), pp. 840. Date of Electronic Publication: 2024 Jan 29. |
DOI: | 10.1038/s41467-024-45080-x |
Abstrakt: | Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by dysregulated B cell compartment responsible for the production of autoantibodies. Here, we show that T cell-specific expression of calcium/calmodulin-dependent protein kinase IV (CaMK4) leads to T follicular helper (T (© 2024. The Author(s).) |
Databáze: | MEDLINE |
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