Phenotypic Analysis of Circulating Myeloid Derived Suppressor Cells and Their Subpopulations in Egyptian Females with Breast Cancer: A Single-Centre Case-Control Study.

Autor:	Saed SM; Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt., Abbas S; Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt., El Ansary MS; Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt., Abdelfattah W; Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt., Maurice KK; Department of General Surgery, Faculty of Medicine, Cairo University, Egypt., Mohamed ME; Department of Anatomic Pathology, Faculty of Medicine, Cairo University, Egypt., Tawfik Koptan DM; Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt.
Jazyk:	angličtina
Zdroj:	Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2024 Jan 01; Vol. 25 (1), pp. 257-263. Date of Electronic Publication: 2024 Jan 01.
DOI:	10.31557/APJCP.2024.25.1.257
Abstrakt:	Background: Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with suppressive function that has been thoroughly documented in the setting of cancer. Our purpose was to evaluate levels of MDSC and their subsets in a cohort of Egyptian patients with breast cancer. Methods: Evaluation of peripheral blood total MDSC and its subset was done using multicolor flowcytometry in 30 malignant, 10 benign breast tumor patients and 10 healthy control females. Results: BC patients had higher total MDSC levels compared to controls (p= 0.01) particularly the Monocytic MDSC (M-MDSC) and abnormal MDSC subsets (p = 0.001 and p <0.001, respectively). A tumor size > 2 cm exhibited significantly higher granulocytic MDSCs (G-MDSCs) compared to tumor size < 2 cm (p= 0.02) whereas abnormal MDSCs were significantly higher in patients with a tumor size < 2 cm (p = 0.037). Conclusion: MDSC and its subsets can be used as a prognostic marker of tumor size as well as a potential targets for treatment in breast cancer patients.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu