Quinoa alleviates osteoporosis in ovariectomized rats by regulating gut microbiota imbalance.

Autor: Dou J; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China., Liang Z; School of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, China., Liu J; Zhong Li Science and Technology Limited Company, Beijing, China., Liu N; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China., Hu X; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China., Tao S; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China., Zhen X; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China., Yang L; Tangshan Maternal and Child Health Care Hospital, Tangshan, China., Zhang J; Tangshan Maternal and Child Health Care Hospital, Tangshan, China., Jiang G; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Jazyk: angličtina
Zdroj: Journal of the science of food and agriculture [J Sci Food Agric] 2024 Jul; Vol. 104 (9), pp. 5052-5063. Date of Electronic Publication: 2024 Feb 15.
DOI: 10.1002/jsfa.13339
Abstrakt: Background: Postmenopausal osteoporosis (PMO) is associated with dysregulation of bone metabolism and gut microbiota. Quinoa is a grain with high nutritional value, and its effects and potential mechanisms on PMO have not been reported yet. Therefore, the purpose of this study is to investigate the bone protective effect of quinoa on ovariectomy (OVX) rats by regulating bone metabolism and gut microbiota.
Results: Quinoa significantly improved osteoporosis-related biochemical parameters of OVX rats and ameliorated ovariectomy-induced bone density reduction and trabecular structure damage. Quinoa intervention may repair the intestinal barrier by upregulating the expression of tight junction proteins in the duodenum. In addition, quinoa increased the levels of Firmicutes, and decreased the levels of Bacteroidetes and Prevotella, reversing the dysregulation of the gut microbiota. This may be related to estrogen signaling pathway, secondary and primary bile acid biosynthesis, benzoate degradation, synthesis and degradation of ketone bodies, NOD-like receptor signaling pathway and biosynthesis of tropane, piperidine and pyridine alkaloids. Correlation analysis showed that there is a strong correlation between gut microbiota with significant changes in abundance and parameters related to osteoporosis.
Conclusion: Quinoa could significantly reverse the high intestinal permeability and change the composition of gut microbiota in OVX rats, thereby improving bone microstructure deterioration and bone metabolism disorder, and ultimately protecting the bone loss of OVX rats. © 2024 Society of Chemical Industry.
(© 2024 Society of Chemical Industry.)
Databáze: MEDLINE
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