Economic and humanistic burden in kidney transplant rejection: a literature review.
| Autor: | Moss E; Health Economics, RTI Health Solutions, Manchester, UK., Burrell A; Founder, Anita Burrell Consulting LLC, Flemington, NJ, USA., Lee J; CSL Behring LLC, King of Prussia, PA, USA., Reichenbach D; CSL Behring LLC, King of Prussia, PA, USA., Mitchell S; Health Economics, RTI Health Solutions, Manchester, UK., Yan S; CSL Behring LLC, King of Prussia, PA, USA., Thiruvillakkat K; CSL Behring LLC, King of Prussia, PA, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Expert review of pharmacoeconomics & outcomes research [Expert Rev Pharmacoecon Outcomes Res] 2024 Mar; Vol. 24 (3), pp. 343-352. Date of Electronic Publication: 2024 Jan 29. |
| DOI: | 10.1080/14737167.2024.2305140 |
| Abstrakt: | Introduction: Antibody-mediated rejection (ABMR) is a major cause of late kidney allograft failure, but its economic and humanistic impacts have not been well-characterized in the literature. Areas Covered: We reviewed available literature on economic burden (costs and healthcare resource use) and humanistic burden (health-related quality of life impacts [HRQOL] and utility estimates) in patients diagnosed with kidney transplant rejection; ABMR-specific studies were of particular interest. In total, 21 publications reporting economic and humanistic burden were included in the review; 9 of these reported ABMR-specific outcomes. The reviewed studies consistently showed a greater burden associated with ABMR-related transplant rejection than with non-ABMR transplant rejection. Expert Opinion: Evidence suggests greater economic burden and increased HRQOL impairment with ABMR-related kidney transplant rejection relative to non-ABMR, although small sample sizes and missing definitions for ABMR make meaningful comparisons between studies challenging. Because no International Classification of Diseases (ICD)-10 codes currently describe the etiologies of transplant rejection, it is difficult to characterize the burden of distinct types of transplant rejection. The paucity of high-quality data on the burden of ABMR in kidney transplant rejection demonstrates the need for more etiology-centric ICD-10 codes. |
| Databáze: | MEDLINE |
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