| Autor: |
Karimi A; Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran., Kohpeyma F; Endocrine and Metabolism Research Center, Shiraz University of Medical Science, Shiraz, Iran., Asadi E; Department of Biology, University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada., Ziyaee M; Abadan University of Medical Science, Abadan, Iran., Karimi S; Department of Anatomical Sciences, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran. |
| Jazyk: |
angličtina |
| Zdroj: |
Zygote (Cambridge, England) [Zygote] 2024 Apr; Vol. 32 (2), pp. 139-148. Date of Electronic Publication: 2024 Jan 29. |
| DOI: |
10.1017/S0967199423000643 |
| Abstrakt: |
Men with diabetes frequently experience spermatogenic dysfunction, which is the most significant sign that diabetes has harmed their ability to reproduce. The effect of various doses of the hydro-alcoholic extract of Nerium oleander leaves on the pituitary-gonadal axis, sperm motility and number, antioxidant system, changes in testicular tissue structure, and spermatogenesis in healthy and diabetic rats has been examined in the current study. Eighty male rats that had been streptozotocin-induced diabetic and healthy were divided into eight groups: (1) control, (2) Nerium (50 mg/kg), (3) Nerium (100 mg/kg), (4) Nerium (200 mg/kg), (5) DM (6) DM+ Nerium (50 mg/kg), (7) DM+ Nerium (100 mg/kg) and (8) DM+ Nerium (200 mg/kg) and were administered orally for 48 days consecutive. Following the studies, analysis of the testicular tissues' antioxidant capacity as well as sperm parameters, Johnsen's scoring and morphometric evaluation, histology, biochemical and stereology studies were performed.The outcomes showed that Nerium 50 and 100 mg/kg considerably enhanced the testicular morphology, sperm parameters, and reproductive organs to varying degrees in diabetic rats. After Nerium 50 mg/kg administration, glutathione peroxidase (GPX) and catalase (CAT) levels in the testicular tissue were increased whereas malondialdehyde (MDA) levels were markedly decreased. Nerium may help protect against diabetic-induced spermatogenic dysfunction in male rats by enhancing the activities of antioxidant enzymes in lower dosages. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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