The emerging role for neutrophil mitochondrial metabolism in lung inflammation.
| Autor: | Maldarelli ME; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Noto MJ; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Immunometabolism (Cobham, Surrey) [Immunometabolism (Cobham)] 2024 Jan 25; Vol. 6 (1), pp. e00036. Date of Electronic Publication: 2024 Jan 25 (Print Publication: 2024). |
| DOI: | 10.1097/IN9.0000000000000036 |
| Abstrakt: | Recent advances shed light on the importance of mitochondrial metabolism in supporting essential neutrophil functions such as trafficking, NETosis, bacterial killing, and modulating inflammatory responses. Mitochondrial metabolism is now recognized to contribute to a number of lung diseases marked by neutrophilic inflammation, including bacterial pneumonia, acute lung injury, and chronic obstructive pulmonary disease. In this mini review, we provide an overview of neutrophil metabolism focusing on the role of mitochondrial programs, discuss select neutrophil effector functions that are directly influenced by mitochondrial metabolism, and present what is known about the role for mitochondrial metabolism in lung diseases marked by neutrophilic inflammation. Competing Interests: M.E.M. has no conflicts of interest. M.J.N. has no conflicts of interest. (Copyright © 2024 The Author(s), Published by Wolters Kluwer Health, Inc.) |
| Databáze: | MEDLINE |
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