Safety and hemostatic effect of Achillea millefolium L. in localized bleeding.

Autor:	Bagheri A; Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.; Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Amin G; Department of Pharmacognosy and Medicinal Plants Reasearch Center, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran., Tavangar SM; Department of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran., Heidari M; Department of Neurology, Iran University of Medical Science, Tehran, Iran., Bagheri J; Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.; Department of Cardiac Surgery, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Hepatology forum [Hepatol Forum] 2024 Jan 16; Vol. 5 (1), pp. 25-27. Date of Electronic Publication: 2024 Jan 16 (Print Publication: 2024).
DOI:	10.14744/hf.2022.2022.0041
Abstrakt:	Background and Aim: This study aims to demonstrate the hemostatic effect of the hydroalcoholic extract of Achillea millefolium L. in localized bleeding and to assess the safety of its topical application on rat liver. Materials and Methods: The aerial parts of A. millefolium were macerated in methanol for two days. Twelve female Wistar rats, weighing 120-220 g, underwent anesthesia and laparotomy. The liver was exposed, and two incisions were made to induce bleeding. One incision was treated with a sponge soaked in A. millefolium extract, while the other served as a control. The animals were divided into two groups: in one, A. millefolium (150 mg/kg) was applied to the first incision, and in the other, to the second incision. Liver biopsies were collected after 4, 6, and 8 weeks. Results: Application of A. millefolium to liver incisions, whether first or second, significantly reduced bleeding time (by 36.1% and 31.9%, respectively). Histopathological analysis showed no signs of toxicity or hepatic damage after 4, 6, and 8 weeks in the female rats. Conclusion: The study confirms the hemostatic effect of the hydroalcoholic extract of A. millefolium in localized bleeding and establishes its safety for topical use. Competing Interests: The authors have no conflict of interest to declare. (© Copyright 2024 by Hepatology Forum.)
Databáze:	MEDLINE
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