Guggulsterone - a potent bioactive phytosteroid: synthesis, structural modification, and its improved bioactivities.

Autor:	Adarsh Krishna TP; R & D Division, Sreedhareeyam Farmherbs India Pvt. Ltd Kerala 686 662 India adarshkrishnatp@gmail.com., Ajeesh Krishna TP; Division of Plant Molecular Biology and Biotechnology, Department of Bioscience, Rajagiri College of Social Sciences Kochi Kerala 683 104 India.; Division of Phytochemistry and Drug-Design, Department of Bioscience, Rajagiri College of Social Sciences Kochi Kerala 683 104 India., Edachery B; R & D Division, Sreedhareeyam Farmherbs India Pvt. Ltd Kerala 686 662 India adarshkrishnatp@gmail.com., Antony Ceasar S; Division of Plant Molecular Biology and Biotechnology, Department of Bioscience, Rajagiri College of Social Sciences Kochi Kerala 683 104 India.; Division of Phytochemistry and Drug-Design, Department of Bioscience, Rajagiri College of Social Sciences Kochi Kerala 683 104 India.
Jazyk:	angličtina
Zdroj:	RSC medicinal chemistry [RSC Med Chem] 2023 Nov 02; Vol. 15 (1), pp. 55-69. Date of Electronic Publication: 2023 Nov 02 (Print Publication: 2024).
DOI:	10.1039/d3md00432e
Abstrakt:	Guggulsterone is a phytosteroid derived from the oleo-gum resin of the critically endangered plant Commiphora wightii . This molecule has attracted increasing attention due to its excellent biochemistry potential and the compound has consequently been evaluated in clinical trials. With a low concentration in natural resources but wide medicinal and therapeutic value, chemists have developed several synthetic routes for guggulsterone starting from various steroid precursors. Moreover, numerous studies have attempted to modify its structure to improve the biological properties. Nowadays, green and sustainable chemistry has also attracted more attention for advanced chemical processes and reactions in steroid chemistry. The present review aimed to summarize the literature and provide an update about the improvements in the chemical synthesis and structural modification of guggulsterone from the view of green chemistry. Moreover, this review encompasses the improved activities of structurally modified guggulsterone derivatives. We expect that the information provided here will be useful to researchers working in this field and on this molecule. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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