Genetic characterization of methicillin-resistant / susceptible Staphylococcus aureus (MRSA/MSSA) and Staphylococcus argenteus clinical isolates in Bangladesh: Dominance of ST6-MRSA-IV/t304 and detection of cfr / fexA in ST8-MSSA/t008.

Autor:	Roy S; Department of Microbiology, Mymensingh Medical College, Mymensingh, Bangladesh., Aung MS; Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan., Paul SK; Netrokona Medical College, Netrokona, Bangladesh., Nasreen SA; Department of Microbiology, Mymensingh Medical College, Mymensingh, Bangladesh., Haque N; Department of Microbiology, Mymensingh Medical College, Mymensingh, Bangladesh., Mazid R; Department of Microbiology, Bangladesh Institute of Health Sciences (BIHS) General Hospital, Dhaka, Bangladesh., Khan MS; Department of Oral Microbiology, Mymensingh Medical College, Mymensingh, Bangladesh., Barman TK; Medicine Unit, Mymensingh Medical College Hospital, Mymensingh, Bangladesh., Arafa P; Department of Microbiology, Mymensingh Medical College, Mymensingh, Bangladesh., Sathi FA; Department of Microbiology, Mymensingh Medical College, Mymensingh, Bangladesh., Nila SS; Department of Microbiology, Mymensingh Medical College, Mymensingh, Bangladesh., Jahan A; Microbiology Department, Pabna Medical College, Pabna, Bangladesh., Urushibara N; Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan., Kawaguchiya M; Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan., Ohashi N; Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan., Kobayashi N; Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
Jazyk:	angličtina
Zdroj:	IJID regions [IJID Reg] 2023 Dec 23; Vol. 10, pp. 132-139. Date of Electronic Publication: 2023 Dec 23 (Print Publication: 2024).
DOI:	10.1016/j.ijregi.2023.12.006
Abstrakt:	Objectives: Coagulase-positive staphylococcus (CoPS), represented by Staphylococcus aureus , is a major cause of infections in humans. This study aimed to investigate molecular epidemiological characteristics, antimicrobial resistance, and their trends of CoPS in Bangladesh. Methods: Clinical isolates of CoPS were collected from two medical institutions in Bangladesh for a 2-year period and analyzed for their species, genotypes, virulence factors, antimicrobial susceptibility, and resistance determinants. Results: 172 CoPS isolates collected were identified as S. aureus or S. argenteus (170 and two, respectively). Methicillin-resistant S. aureus (MRSA) accounted for 36% (n = 61), having Staphylococcal cassette chromosome mec (SCC mec )-IV (82%) or V (18%). Panton-Valentine leukocidin (PVL) genes were detected at higher rate in methicillin-susceptible S. aureus (MSSA) (62%) than MRSA (26%). MRSA comprised 11 STs, including a dominant type ST6 (46%) associated with mostly SCC mec- IVa/ spa -t304, and one isolate had genetic features of the USA300 clone (ST8/SCC mec -IVa/ coa -IIIa/ spa -t008/ACME-I/ΦSa2USA). STs of CC1, CC88, and CC398 were common in MSSA, with CC88 showing the highest PVL-positive rate. One MSSA isolate (ST8/ spa -t008) harbored fexA and cfr showing susceptibility to linezolid. S. argenteus was methicillin-susceptible and belonged to ST2250/ coa -XId. Conclusions: Genetic characteristics of current MRSA/MSSA in Bangladesh were revealed, with first identification of S. argenteus at low prevalence. Competing Interests: The authors have no competing interests to declare. (© 2023 The Author(s).)
Databáze:	MEDLINE
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