Cachexia Prevalence in a Population of Moroccan Women with Rheumatoid Arthritis.

Autor:	Toufik H; Rheumatology Department, Military Hospital Mohammed V, Rabat, Morocco., Ouardi NE; Rheumatology Department, Military Hospital Mohammed V, Rabat, Morocco., Ghassem MA; Rheumatology Department, Military Hospital Mohammed V, Rabat, Morocco., Djossou JH; Rheumatology Department, Military Hospital Mohammed V, Rabat, Morocco., Taoubane L; Rheumatology Department, Military Hospital Mohammed V, Rabat, Morocco., Majjad A; Rheumatology Department, Military Hospital Mohammed V, Rabat, Morocco., Maghraoui AE; Cabinet of Rheumatology, Rabat, Morocco., Bezza A; Rheumatology Department, Military Hospital Mohammed V, Rabat, Morocco.
Jazyk:	angličtina
Zdroj:	Mediterranean journal of rheumatology [Mediterr J Rheumatol] 2023 Aug 25; Vol. 34 (4), pp. 506-512. Date of Electronic Publication: 2023 Aug 25 (Print Publication: 2023).
DOI:	10.31138/mjr.250823.cpp
Abstrakt:	Objective: To assess body composition in women with rheumatoid arthritis (RA) compared to healthy controls, to calculate the prevalence of rheumatoid Cachexia (RC), and to identify the associated factors. Methods: We conducted a case-control study on 112 female patients with RA according to the 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for RA; and 224 age-matched healthy women. Body composition (BC) and bone mineral density (BMD) scans were obtained using Dual-energy X-ray absorptiometry (DXA). RC was defined by a fat-free mass index (FFMI) below the 10 th percentile and a fat mass index (FMI) above the 25 th percentile compared with the control group. We conducted a comparison between RA patients and healthy controls then a multiple regression analysis was conducted where the dependant variable is the presence of RC. Results: RC prevalence was 42.85% while the mean body mass index (BMI) was the same in both groups. RA patients had a higher FM and lower FFM comparing to healthy controls. In our population, 78.60% of patients were on methotrexate and 12.50% on anti TNF therapy. Comparison between patients with and without RC showed that patients with RC have a higher proportion of erosive arthritis and of active disease. Regression logistic analysis showed that RC was significantly associated to erosive arthritis and active disease (OR at 33.31 (8.42-131.70) and 8.98 (1.64-49.20) respectively), independently of age, erythrocyte sedimentation rate, C-reactive protein, disease duration, steroid cumulative dose and biologic Disease-Modifying Anti-Rheumatic Drugs(bDMARDs) use. Conclusion: Our study showed that almost half of our RA patients have RC, even with a high BMI. Competing Interests: The authors declare that they have no competing interests. (© 2023 The Mediterranean Journal of Rheumatology (MJR).)
Databáze:	MEDLINE
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