Assessing regional hepatic function changes after hypertrophy induction by radioembolisation: comparison of gadoxetic acid-enhanced MRI and 99m Tc-mebrofenin hepatobiliary scintigraphy.

Autor: Fabritius MP; Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany. Matthias.fabritius@med.lmu.de., Garlipp B; General Surgery, Otto Von Guericke University, Magdeburg, Germany., Öcal O; Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany., Puhr-Westerheide D; Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany., Amthauer H; Department of Nuclear Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany., Geyer T; Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany., Holzgreve A; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany., Ricke J; Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany., Kupitz D; Department of Radiology and Nuclear Medicine, University Hospital Magdeburg and Medical Faculty of Otto-Von-Guericke University, Magdeburg, Germany., Grosser OS; Department of Radiology and Nuclear Medicine, University Hospital Magdeburg and Medical Faculty of Otto-Von-Guericke University, Magdeburg, Germany.; Research Campus STIMULATE, Otto-Von-Guericke University, Magdeburg, Germany., Omari J; Department of Radiology and Nuclear Medicine, University Hospital Magdeburg and Medical Faculty of Otto-Von-Guericke University, Magdeburg, Germany., Pech M; Department of Radiology and Nuclear Medicine, University Hospital Magdeburg and Medical Faculty of Otto-Von-Guericke University, Magdeburg, Germany., Seidensticker M; Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany., Grawe F; Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany. Freba.Grawe@med.uni-muenchen.de., Seidensticker R; Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Jazyk: angličtina
Zdroj: European radiology experimental [Eur Radiol Exp] 2024 Jan 29; Vol. 8 (1), pp. 15. Date of Electronic Publication: 2024 Jan 29.
DOI: 10.1186/s41747-023-00409-x
Abstrakt: Background: To compare Gd-ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) and 99m Tc-labelled mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests after unilateral radioembolisation (RE) in patients with primary or secondary liver malignancies.
Methods: Twenty-three patients with primary or secondary liver malignancies who underwent Gd-EOB-DTPA-enhanced MRI within a prospective study (REVoluTion) were evaluated. REVoluTion was a prospective open-label, non-randomised, therapy-optimising study of patients undergoing right-sided or sequential RE for contralateral liver hypertrophy at a single centre in Germany. MRI and hepatobiliary scintigraphy were performed before RE (baseline) and 6 weeks after (follow-up). This exploratory subanalysis compared liver enhancement on hepatobiliary phase MRI normalised to the spleen (liver-to-spleen ratio (LSR)) and the muscle (liver-to-muscle ratio (LMR)) with mebrofenin uptake on HBS for the total liver (TL) and separately for the right (RLL) and left liver lobe (LLL).
Results: Mebrofenin uptake at baseline and follow-up each correlated significantly with LSR and LMR on MRI for TL (≤ 0.013) and RLL (≤ 0.049). Regarding the LLL, mebrofenin uptake correlated significantly with LMR (baseline, p = 0.013; follow-up, p = 0.004), whereas with LSR, a borderline significant correlation was only seen at follow-up (p = 0.051; p = 0.046).
Conclusion: LSRs and LMR correlate with mebrofenin uptake in HBS. This study indicates that Gd-EOB-DTPA-enhanced MRI and 99m Tc-labelled mebrofenin HBS may equally be used to assess an increase in contralateral liver lobe function after right-sided RE.
Relevance Statement: MRI may be a convenient and reliable method for assessing the future liver remnant facilitating treatment planning and monitoring of patients after RE-induced hypertrophy induction.
Key Points: • Both MRI and HBS can assess liver function after RE. • Liver enhancement on MRI correlates with mebrofenin uptake on HBS. • MRI might be a convenient alternative for estimating future liver remnants after hypertrophy induction.
(© 2024. The Author(s).)
Databáze: MEDLINE
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