Anal and Perianal Preneoplastic Lesions.
| Autor: | Loughrey MB; Department of Cellular Pathology, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland BT12 6BA, United Kingdom. Electronic address: maurice.loughrey@belfasttrust.hscni.net., Shepherd NA; Gloucestershire Cellular Pathology Laboratory, Cheltenham General Hospital, Sandford Road, Cheltenham GL53 7AN, United Kingdom. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Gastroenterology clinics of North America [Gastroenterol Clin North Am] 2024 Mar; Vol. 53 (1), pp. 201-220. Date of Electronic Publication: 2023 Oct 16. |
| DOI: | 10.1016/j.gtc.2023.09.007 |
| Abstrakt: | Anal cancer, mainly squamous cell carcinoma, is rare but increasing in prevalence, as is its precursor lesion, anal squamous dysplasia. They are both strongly associated with human papillomavirus infection. The 2-tiered Lower Anogenital Squamous Terminology classification, low-grade SIL and high-grade SIL, is preferred to the 3-tiered anal intraepithelial neoplasia classification because of better interobserver agreement and clearer management implications. Immunohistochemistry with p16 is helpful to corroborate the diagnosis of squamous dysplasia. Similarly, immunohistochemistry is helpful to differentiate primary Paget disease from secondary Paget disease, which is usually due to anal squamous mucosal/epidermal involvement by primary rectal adenocarcinoma. Competing Interests: Disclosure Neither author has any conflicts of interest to disclose. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|