A model about regulation on three division modes of stem cell.

Autor: Xie Q; School of Science, Nanjing University of Science and Technology, Nanjing 210094, China., Zhang H; School of Science, Nanjing University of Science and Technology, Nanjing 210094, China., Wang M; School of Science, Nanjing University of Science and Technology, Nanjing 210094, China. Electronic address: wangmx@njust.edu.cn., Yan K; School of Science, Nanjing University of Science and Technology, Nanjing 210094, China., Hu F; School of Science, Nanjing University of Science and Technology, Nanjing 210094, China., Xu M; School of Science, Nanjing University of Science and Technology, Nanjing 210094, China.
Jazyk: angličtina
Zdroj: Journal of theoretical biology [J Theor Biol] 2024 Mar 21; Vol. 581, pp. 111746. Date of Electronic Publication: 2024 Jan 26.
DOI: 10.1016/j.jtbi.2024.111746
Abstrakt: We construct a multi-stage cell lineage model for cell division, apoptosis and movement. Cells are assumed to secrete and respond to negative feedback molecules which act as a control on the stem cell divisions (including self-renewal, asymmetrical cell division (ACD) and differentiation). The densities of cells and molecules are described by coupled reaction-diffusion partial differential equations, and the plane wavefront propagation speeds can be obtained analytically and verified numerically. It is found that with ACD the population and propagation of stem cells can be promoted but the negative regulation on self-renewal and differentiation will work slowly. Regulatory inhibition on differentiation will inversely increase stem cells but not affect the population and wave propagation of the cell lineage. While negative regulation on self-renewal and ACD will decrease the population of stem cells and slow down the propagation, and even drive stem cells to extinction. Moreover we find that inhibition on self-renewal has a strength advantage while inhibition on ACD has a range advantage to kill stem cells. Possible relations to model cancer development and therapy are also discussed.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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