Migraine headache and aura induced by hypoxia.

Autor: Al-Karagholi MA; Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Arngrim N; Department of Neurology, Odense University Hospital, Denmark., Ashina M; Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Danish Knowledge Center on Headache Disorders, Glostrup, Denmark.
Jazyk: angličtina
Zdroj: The Journal of physiology [J Physiol] 2024 Nov; Vol. 602 (21), pp. 5515-5522. Date of Electronic Publication: 2024 Jan 27.
DOI: 10.1113/JP284553
Abstrakt: Migraine, a common neurological disorder, impacts over a billion individuals globally. Its complex aetiology involves various signalling cascades. Hypoxia causes headaches such as high-altitude headache and acute mountain sickness which share phenotypical similarities with migraine. Epidemiological data indicate an increased prevalence of migraine with and without aura in high-altitude populations. Experimental studies have further shown that hypoxia can induce migraine attacks. This review summarizes evidence linking hypoxia to migraine, delves into potential pathophysiological mechanisms and highlights research gaps.
(© 2024 The Authors. The Journal of Physiology © 2024 The Physiological Society.)
Databáze: MEDLINE
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