Epidemiology of Vancomycin in Combination With Piperacillin/Tazobactam-Associated Acute Kidney Injury in Children: A Systematic Review and Meta-analysis.

Autor:	Zhang M; Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.; Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.; West China School of Pharmacy, Sichuan University, Chengdu, China., Huang L; Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.; Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China., Zhu Y; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.; Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China., Zeng L; Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.; Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China., Jia ZJ; Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.; Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.; West China School of Pharmacy, Sichuan University, Chengdu, China., Cheng G; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.; Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Sichuan University, Chengdu, China., Li H; Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.; Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China., Zhang L; Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.; Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.; NMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.; Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
Jazyk:	angličtina
Zdroj:	The Annals of pharmacotherapy [Ann Pharmacother] 2024 Oct; Vol. 58 (10), pp. 1034-1044. Date of Electronic Publication: 2024 Jan 27.
DOI:	10.1177/10600280231220379
Abstrakt:	Background: Several studies have shown that vancomycin combined with piperacillin/tazobactam (VPT) increased the risk of acute kidney injury (AKI) compared with other antibiotics in children. However, the epidemiology of VPT-associated AKI in children is unknown. Objective: To evaluate the incidence and risk factors of VPT-associated AKI in children. Data Sources: Literature databases of PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP Database, WanFang Database, and China Biology Medicine Disc were searched from inception to November 2023. References of included studies were also manually checked. Study Selection and Data Extraction: Two independent reviewers selected studies, extracted data, and quality assessment. Meta-analyses were performed to quantify the incidence and risk factors of VPT-associated AKI in children. Data Synthesis: Sixteen cohort studies were identified. Overall, the incidence of VPT-associated AKI in children was 24.3% (95% CI: 17.9%-30.6%). The incidence of VPT-associated AKI in critically ill children (26.6%) was higher than that in noncritically ill children (10.9%). Moreover, higher serum vancomycin trough concentration (>15 mg/L), use of vasopressors, combination of nephrotoxins and intensive care unit admission were risk factors for VPT-associated AKI in children ( P  < 0.05). Relevance to Patient Care and Clinical Practice: Identifying high-risk groups and determining safer treatments is critical to reducing the incidence of VPT-associated AKI in children. Conclusions: The incidence of VPT-associated AKI in children is high, especially in critically ill children. Medication regimens should be personalized based on the presence of individual risk factors. Moreover, renal function was regularly assessed throughout treatment with VPT. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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