Bone Metabolism in Men who Live with HIV Aged 50 years and Over: Impact of Infection Duration.

Autor:	Caglar B; Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa School of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey., Durcan E; Department of Endocrinology, Cerrahpasa School of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey., Karaali R; Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa School of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey., Balkan II; Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa School of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey., Kaya SY; Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa School of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey., Yavuzer H; Department of Geriatrics, Cerrahpasa School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey., Konukoglu D; Department of Medical Biochemistry, Cerrahpasa School of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey., Aygun G; Department of Medical Microbiology, Cerrahpasa School of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey., Saltoglu N; Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa School of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey., Bulut IN; Department of Radiology, Cerrahpasa School of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey., Sonmezoglu K; Department of Nuclear Medicine, Cerrahpasa School of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey., Kadioglu P; Department of Endocrinology, Cerrahpasa School of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey., Mete B; Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa School of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey., Tabak OF; Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa School of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Current HIV research [Curr HIV Res] 2024; Vol. 22 (1), pp. 65-71.
DOI:	10.2174/011570162X273667231213061301
Abstrakt:	Background: Early diagnosis and effective antiretroviral therapy (ART) lead to similar life expectancy in people living with HIV (PLWH) compared to the general population. This population faces problems such as decreased bone mineral density (BMD) and increased fracture risk. The aim of this study was to determine the prevalence of osteoporosis in men aged 50 years and over who were PLWH and to determine risk factors and changes in bone metabolism with bone turnover markers. Methods: 79 male PLWH aged 50 years and over were followed up in our outpatient clinic between May 2021 and October 2021. The patients' demographic, clinical, laboratory, and DEXA data were analyzed. Serum levels of bone turnover markers were measured. Results: The prevalence of osteopenia, osteoporosis, and normal BMD was found to be 55.7%, 13.9%, and 30.4%, respectively. A correlation was found between low BMD and low body mass index, elapsed time since diagnosis of HIV infection, high rate of use of ART, and long usage time of tenofovir disoproxil fumarate + protease inhibitor. A one-year increase in HIV infection duration was associated with an increased risk of low BMD by 1.246. Conclusion: Compared to studies conducted on the general population, the prevalence of osteoporosis in male PLWH aged 50 years and older was two times higher. The limited effect of the duration of ART use on low BMD may be due to the patients' histories of replacement therapy. Therefore, to eliminate the negative effects of ART on BMD, it may be beneficial to start replacement therapy when necessary. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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