Highly Sensitive Early Diagnosis of Kidney Damage Using Renal Clearable Zwitterion-Coated Ferrite Nanoprobe via Magnetic Resonance Imaging In Vivo.

Autor: Zhou T; School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, China., Dong Y; School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, China., Wang X; Department of Radiology and Ultrasound, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China., Liu R; Department of Rehabilitation, School of Medical Technology, Tianjin Medical University, Tianjin, 300203, China., Cheng R; School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, China., Pan J; Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical, University General Hospital, Tianjin, 300052, China., Zhang X; School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, China., Sun SK; School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, China.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 May; Vol. 13 (12), pp. e2304577. Date of Electronic Publication: 2024 Feb 07.
DOI: 10.1002/adhm.202304577
Abstrakt: Iron oxide nanoprobes exhibit substantial potential in magnetic resonance imaging (MRI) of kidney diseases and can eliminate the nephrotoxicity of gadolinium-based contrast agents (GBCAs). Nevertheless, there is an extreme shortage of highly sensitive and renal clearable iron oxide nanoprobes suitable for early kidney damage detection through MRI. Herein, a renal clearable ultra-small ferrite nanoprobe (UMFNPs@ZDS) is proposed for highly sensitive early diagnosis of kidney damage via structural and functional MRI in vivo for the first time. The nanoprobe comprises a ferrite core coated with a zwitterionic layer, and possesses a high T 1 relaxivity (12.52 mm -1 s -1 ), a small hydrodynamic size (6.43 nm), remarkable water solubility, excellent biocompatibility, and impressive renal clearable ability. In a rat model of unilateral ureteral obstruction (UUO), the nanoprobe-based MRI can not only accurately visualize the locations of renal injury, but also provide comprehensive functional data including peak value, peak time, relative renal function (RRF), and clearance percentage via MRI. The findings prove the immense potential of ferrite nanoprobes as a superior alternative to GBCAs for the early diagnosis of kidney damage.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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