Arsenic trioxide inhibits the response of primary human B cells to influenza virus A in vitro.

Autor: Kaiser LM; College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States of America., Freeborn RA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States of America., Boss AP; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States of America; Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, United States of America., Jin Y; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States of America., Rockwell CE; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States of America; Applied Immunology Center for Research and Education, Michigan State University, East Lansing, United States of America. Electronic address: rockwelc@msu.edu.
Jazyk: angličtina
Zdroj: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2024 Apr; Vol. 96, pp. 105783. Date of Electronic Publication: 2024 Jan 24.
DOI: 10.1016/j.tiv.2024.105783
Abstrakt: Arsenic compounds are common environmental toxicants worldwide and particularly enriched in the Northeast and the Southwestern United States, the Alps, and Bangladesh. Exposure to arsenic is linked with various detrimental health outcomes, including cancer, cognitive decline, and kidney damage. Our group has previously shown that arsenic trioxide alters T cell cytokine production. In the current study, we demonstrate that exposure to arsenic compounds alters B cell function in an in vitro influenza model. Human peripheral blood mononuclear cells (PBMCs) were isolated from blood and cultured with arsenic trioxide (As 3 O 2 ) and subsequently challenged with Influenza A virus. B cells showed decreased expression of CD267, surface IgG and CD80 when treated with As 3 O 2 . Taken together, the data suggest that As 3 O 2 affects the activation and surface antibody expression of human peripheral B cells. Overall, this suggests that As 3 O 2 exposure could cause impaired humoral immunity.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Cheryl Rockwell reports financial support was provided by National Institute of Environmental Health Sciences.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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