Autologous platelet-rich plasma (APRP) in diabetes foot disease: a meta-analysis.

Autor: Ruiz-Muñoz M; Department Nursing and Podiatry, Faculty of Health Sciences, University of Málaga, Málaga, Spain. Electronic address: marumu@uma.es., Martinez-Barrios FJ; Department Nursing and Podiatry, Faculty of Health Sciences, University of Málaga, Málaga, Spain. Electronic address: frjmb@uma.es., Fernandez-Torres R; Department Nursing and Podiatry, Faculty of Health Sciences, University of Málaga, Málaga, Spain. Electronic address: fernandeztorres@uma.es., Lopezosa-Reca E; Department Nursing and Podiatry, Faculty of Health Sciences, University of Málaga, Málaga, Spain. Electronic address: evalopezosa@uma.es., Marchena-Rodriguez A; Department Nursing and Podiatry, Faculty of Health Sciences, University of Málaga, Málaga, Spain. Electronic address: amarchena@uma.es.
Jazyk: angličtina
Zdroj: Journal of diabetes and its complications [J Diabetes Complications] 2024 Feb; Vol. 38 (2), pp. 108690. Date of Electronic Publication: 2024 Jan 19.
DOI: 10.1016/j.jdiacomp.2024.108690
Abstrakt: Introduction: This study will explore the effectiveness of autologous platelet-rich plasma in the treatment of diabetic foot disease compared to conventional treatments, based on the ulcer healing rate.
Methods: The electronic databases of PubMed, EMBASE, and WOS internet were searched. Evaluated outcome rate of complete ulcer healing. Statistical analysis was performed with RevMan 5.0 software and SPSS 25.0.
Results: Eleven RCTs with 828 patients were included in this study. The meta-analysis showed a higher complete ulcer healing rate (OR = 3.69, 95 % CI 2.62 to 5.20, P < 0.01, I 2  = 0 %) in growth factors based in autologous platelech-rich plasma (aPRP) group compared with control. Mixed evidence was seen for publication bias, but analyses by using the trim-and-fill method did not appreciably alter results.
Conclusion: Autologous platelet-rich plasma can improve the complete healing rate of the ulcer compared to current conventional treatments in diabetic foot ulcer patients.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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