The regulatory effects of mesedin and beditin alpha2-adrenoblockers on the functional activity of the nervous, cardiovascular, and endocrine systems in rats under the hypoxic conditions.

Autor: Manukyan AL; Department of Medical Chemistry, Yerevan State Medical University After M. Heratsi, Koryun 2, 0025, Yerevan, Armenia. manukyanashkhen@mail.ru.; Cobrain Center, Yerevan State Medical University After M. Heratsi, 0025, 2 Koryun Str., Yerevan, Armenia. manukyanashkhen@mail.ru., Melkonyan MM; Department of Medical Chemistry, Yerevan State Medical University After M. Heratsi, Koryun 2, 0025, Yerevan, Armenia.; Cobrain Center, Yerevan State Medical University After M. Heratsi, 0025, 2 Koryun Str., Yerevan, Armenia., Sukiasyan LM; Laboratory of Morphological Studies, SRS, Yerevan State Medical University After M. Heratsi, 0025, Yerevan, Armenia., Vardanyan SO; Scientific-Technological Center of Organic-Pharmaceutical Chemistry of NAS RA, Institute of Fine Organic Chemistry After A.L. Mnjoyan, 0014, Yerevan, Armenia., Hunanyan LS; Department of Medical Chemistry, Yerevan State Medical University After M. Heratsi, Koryun 2, 0025, Yerevan, Armenia.; Cobrain Center, Yerevan State Medical University After M. Heratsi, 0025, 2 Koryun Str., Yerevan, Armenia., Yenkoyan KB; Neuroscience Laboratory, Cobrain Center, Yerevan State Medical University After M. Heratsi, 0025, 2 Koryun Str., Yerevan, Armenia.; Department of Biochemistry, Yerevan State Medical University M. Heratsi, 0025, Yerevan, Armenia., Harutyunyan SH; Scientific-Technological Center of Organic-Pharmaceutical Chemistry of NAS RA, Institute of Fine Organic Chemistry After A.L. Mnjoyan, 0014, Yerevan, Armenia.
Jazyk: angličtina
Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Jul; Vol. 397 (7), pp. 5303-5315. Date of Electronic Publication: 2024 Jan 26.
DOI: 10.1007/s00210-024-02968-1
Abstrakt: One of the reasons of the development of pathologies causing death is hypoxia. The purposes of this study were (1) to study some physiological and biochemical mechanisms of α 2 -adrenoblockers, which ensure the tissue resistance increase to hypoxia; (2) to offer new drugs contributing to the increase of tissues' stability towards the hypoxic affection; and (3) to submit new medications to surpass by their anti-hypoxic activity of those already used in modern medicine and have some advantages. The reactivity of postsynaptic vascular α 2 -adrenoceptors was determined on the damaged spinal cord expressed by the blood pressure increase in response to intravenous administration of azepexole that selectively binds to α 2 -adrenoceptors. Determination of the systemic hemodynamic values and the vascular resistance to the blood flow was performed by the method with plastic microspheres of marked isotopes. pO 2 in the blood and the oxygen-transporting function were determined in a sample of 0.1 ml of blood in 30, 90, and 180 min after the α 2 -adrenoblockers' injections. It has been found that one of the major hemodynamic effects of mesedin and beditin was an improvement in cardiac output, as well as a prolonged increase in coronary blood flow and vasodilation of the heart vessels. Some anti-hypoxic mechanisms of the studied α 2 -adrenoblockers are an improvement of blood oxygen-transporting function followed by tissue oxygenation and the increased level of corticosterone and resistance to hypoxia. Revealing the mechanisms of action of the postsynaptic α 2 -adrenoceptors suggests that mesedin and beditin are potentially effective therapeutic means for many hypoxic conditions.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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