| Autor: |
Miron M; Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa' of Iași, 700115 Iasi, Romania., Blaj M; Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa' of Iași, 700115 Iasi, Romania.; Anesthesiology and Intensive Care Unit, 'Sf. Spiridon' Hospital, 700111 Iasi, Romania., Ristescu AI; Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa' of Iași, 700115 Iasi, Romania.; Anesthesiology and Intensive Care Unit, Regional Institute of Oncology, 700483 Iasi, Romania., Iosep G; Anesthesiology and Intensive Care Unit, Clinical Hospital of Pneumology, 700182 Iasi, Romania., Avădanei AN; Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa' of Iași, 700115 Iasi, Romania., Iosep DG; Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa' of Iași, 700115 Iasi, Romania., Crișan-Dabija R; Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa' of Iași, 700115 Iasi, Romania.; Pulmonology Department, Clinical Hospital of Pneumology, 700182 Iasi, Romania., Ciocan A; Clinical Hospital of Pneumology, 700182 Iasi, Romania., Perțea M; Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa' of Iași, 700115 Iasi, Romania.; Department of Surgery 1, 'Sf. Spiridon' Hospital, 700111 Iasi, Romania., Manciuc CD; Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa' of Iași, 700115 Iasi, Romania.; Clinic of Infectious Diseases, 'Sf. Parascheva' Clinical Hospital of Infectious Diseases, 700116 Iasi, Romania., Luca Ș; Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa' of Iași, 700115 Iasi, Romania., Grigorescu C; Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa' of Iași, 700115 Iasi, Romania.; Thoracic Surgery Department, Clinical Hospital of Pneumology, 700182 Iasi, Romania., Luca MC; Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa' of Iași, 700115 Iasi, Romania.; Clinic of Infectious Diseases, 'Sf. Parascheva' Clinical Hospital of Infectious Diseases, 700116 Iasi, Romania. |
| Abstrakt: |
Hospital-acquired pneumonia (HAP) and its subtype, ventilator-associated pneumonia (VAP), remain two significant causes of morbidity and mortality worldwide, despite the better understanding of pathophysiological mechanisms, etiology, risk factors, preventive methods (bundle of care principles) and supportive care. Prior detection of the risk factors combined with a clear clinical judgement based on clinical scores and dosage of different inflammatory biomarkers (procalcitonin, soluble triggering receptor expressed on myelloid cells type 1, C-reactive protein, mid-regional pro-adrenomedullin, mid-regional pro-atrial natriuretic peptide) represent the cornerstones of a well-established management plan by improving patient's outcome. This review article provides an overview of the newly approved terminology considering nosocomial pneumonia, as well as the risk factors, biomarkers, diagnostic methods and new treatment options that can guide the management of this spectrum of infections. |
