Multiplex Immunofluorescence Captures Progressive Immune Exhaustion with Advancing Penile Squamous Cell Cancer Stage.

Autor: Ionescu F; Genitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Nguyen J; Pathology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Segura CM; Pathology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Paravathaneni M; Genitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Grass GD; Radiation Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Johnstone P; Radiation Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Zacharias NM; Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Pettaway CA; Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Lu X; Department of Biological Sciences, University of Notre Dame, Norte Dame, IN 46556, USA., Kim Y; Biostatistics and Bioinformatics Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Whiting J; Biostatistics and Bioinformatics Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Dhillon J; Pathology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Eschrich SA; Biostatistics and Bioinformatics Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Chadha J; Genitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Gullapalli K; Genitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Roman Souza G; Genitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Miyagi H; Genitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Manley BJ; Genitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Spiess PE; Genitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA., Chahoud J; Genitourinary Oncology Department, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2024 Jan 11; Vol. 16 (2). Date of Electronic Publication: 2024 Jan 11.
DOI: 10.3390/cancers16020303
Abstrakt: Penile squamous cell carcinoma (PSCC) is a rare and deadly malignancy. Therapeutic advances have been stifled by a poor understanding of disease biology. Specifically, the immune microenvironment is an underexplored component in PSCC and the activity of immune checkpoint inhibitors observed in a subset of patients suggests immune escape may play an important role in tumorigenesis. Herein, we explored for the first time the immune microenvironment of 57 men with PSCC and how it varies with the presence of human papillomavirus (HPV) infection and across tumor stages using multiplex immunofluorescence of key immune cell markers. We observed an increase in the density of immune effector cells in node-negative tumors and a progressive rise in inhibitory immune players such as type 2 macrophages and upregulation of the PD-L1 checkpoint in men with N1 and N2-3 disease. There were no differences in immune cell densities with HPV status.
Databáze: MEDLINE
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