| Autor: |
Gargiulo E; Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano, 49, 80131 Napoli, Italy., Roscetto E; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via Pansini 5, 80131 Napoli, Italy., Galdiero U; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via Pansini 5, 80131 Napoli, Italy., Surico G; Department of Agriculture, Food, Environment, and Forestry (DAGRI), Section of Agricultural Microbiology, Plant Pathology and Entomology, University of Florence, 50121 Firenze, Italy., Catania MR; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via Pansini 5, 80131 Napoli, Italy., Evidente A; Institute of Sciences of Food Production, National Research Council, Via Amendola 122/O, 70125 Bari, Italy., Taglialatela-Scafati O; Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano, 49, 80131 Napoli, Italy. |
| Abstrakt: |
Lampedusa, the largest island of the Pelagie archipelago, Sicily, Italy, has proven to be a rich source of plants and shrubs used in folk medicine. These plants, often native to the island, have been very poorly investigated for their phytochemical composition and biological potential to be translated into pharmacological applications. To start achieving this purpose, a specimen of Limonium lopadusanum , a plant native to Lampedusa, was investigated for the first time. This manuscript reports the results of a preliminary biological assay, focused on antimicrobial activity, carried out using the plant organic extracts, and the isolation and chemical and biological characterization of the secondary metabolites obtained. Thus 3-hydroxy-4-methoxybenzoic acid methyl ester ( syn : methyl isovanillate, ( 1 ), methyl syringate ( 2 ), pinoresinol ( 3 ), erythrinassinate C ( 4 ) and tyrosol palmitate ( 5 ) were isolated. Their antimicrobial activity was tested on several strains and compound 4 showed promising antibacterial activity against Enterococcus faecalis . Thus, this metabolite has antibiotic potential against the drug-resistant opportunistic pathogen E. faecalis. |
