Pathogens in Pediatric Septic Arthritis: A Multi-Center Study in Turkiye (PEDSART Study).

Autor:	Iseri Nepesov M; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir 26040, Türkiye., Kilic O; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir 26040, Türkiye., Sali E; Department of Pediatric Infectious Diseases, Umraniye Training and Research Hospital, Istanbul 34764, Türkiye., Yesil E; Department of Pediatric Infectious Diseases, Mersin City Hospital, Mersin 33240, Türkiye., Akar A; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Mersin University, Mersin 33110, Türkiye., Kaman A; Department of Pediatric Infectious Diseases, Dr. Sami Ulus Maternity and Children's Training and Research Hospital, Ankara 06080, Türkiye., Metin Akcan O; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Necmettin Erbakan University, Konya 42090, Türkiye., Kilic Cil M; Department of Pediatric Infectious Diseases, Adana City Hospital, Adana 01230, Türkiye., Ozlu C; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Dokuz Eylul University, Izmir 35210, Türkiye., Lacinel Gurlevik S; Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara 06230, Türkiye., Ulusoy E; Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Health Sciences Izmir Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir 35210, Türkiye., Cetin BS; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri 38030, Türkiye., Akici N; Department of Pediatrics, University of Health Sciences, Haydarpaşa Numune Training and Research Hospital, Istanbul 34668, Türkiye., Cakir D; Department of Pediatric Infectious Diseases, Umraniye Training and Research Hospital, Istanbul 34764, Türkiye., Uslu Aygun FD; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Cerrahpaşa University, Istanbul 34098, Türkiye., Hancerli CO; Department of Orthopedics and Traumatology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul 34303, Türkiye., Tekin Yilmaz A; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Kocaeli University, İzmit 41001, Türkiye., Alkan G; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Selcuk University, Konya 42130, Türkiye., Uygun H; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Adıyaman University, Adıyaman 02040, Türkiye., Bucak IH; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Adıyaman University, Adıyaman 02040, Türkiye., Bursal B; Department of Pediatrics, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul 34303, Türkiye., Celik T; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale 17020, Türkiye., Sutcu M; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Istinye University, Istanbul 34010, Türkiye., Oz FN; Department of Pediatric Infectious Diseases, Dr. Sami Ulus Maternity and Children's Training and Research Hospital, Ankara 06080, Türkiye., Gayretli Aydin ZG; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Türkiye., Karbuz A; Department of Pediatric Infectious Diseases, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul 34384, Türkiye., Akturk H; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Koc University, Istanbul 34010, Türkiye., Kepenekli E; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Marmara University, Istanbul 34854, Türkiye., Emiroglu M; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Selcuk University, Konya 42130, Türkiye., Oncel S; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Kocaeli University, İzmit 41001, Türkiye., Nuhoglu C; Department of Pediatrics, University of Health Sciences, Haydarpaşa Numune Training and Research Hospital, Istanbul 34668, Türkiye., Korucu IH; Department of Orthopedics and Traumatology, Faculty of Medicine, Necmettin Erbakan University, Konya 42090, Türkiye., Incesu M; Department of Orthopedics and Traumatology, University of Health Sciences, Izmir Tepecik Training and Research Hospital, Izmir 35020, Türkiye., Kaya A; Department of Orthopedics and Traumatology, University of Health Sciences, Izmir Tepecik Training and Research Hospital, Izmir 35020, Türkiye., Bombaci H; Department of Orthopedics and Traumatology, University of Health Sciences, Haydarpaşa Numune Training and Research Hospital, Istanbul 34668, Türkiye., Dinleyici M; Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir 26040, Türkiye., Carman KB; Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir 26040, Türkiye., Duman M; Division of Pediatric Emergency Medicine, Department of Pediatrics, Faculty of Medicine, Dokuz Eylul University, Izmir 35160, Türkiye., Turel O; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Medeniyet University, Istanbul 34700, Türkiye., Yilmaz D; Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Health Sciences, Izmir Tepecik Training and Research Hospital, Izmir 35020, Türkiye., Alabaz D; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Cukurova University, Adana 01330, Türkiye., Belet N; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Dokuz Eylul University, Izmir 35210, Türkiye., Tanir G; Department of Pediatric Infectious Diseases, Dr. Sami Ulus Maternity and Children's Training and Research Hospital, Ankara 06080, Türkiye., Turgut M; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Adıyaman University, Adıyaman 02040, Türkiye., Celebi S; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Uludag University, Bursa 16059, Türkiye., Kuyucu N; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Mersin University, Mersin 33110, Türkiye., Arisoy ES; Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Kocaeli University, İzmit 41001, Türkiye., Durmaz G; Department of Microbiology, Faculty of Medicine, Eskişehir Osmangazi University, Eskisehir 26040, Türkiye., Kaya M; Diagen Biotechnological Systems Healthcare and Automation Company, Ankara 06070, Türkiye., Kara A; Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara 06230, Türkiye., Dinleyici EC; Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir 26040, Türkiye.
Jazyk:	angličtina
Zdroj:	Children (Basel, Switzerland) [Children (Basel)] 2024 Jan 22; Vol. 11 (1). Date of Electronic Publication: 2024 Jan 22.
DOI:	10.3390/children11010134
Abstrakt:	Objectives: Septic arthritis (SA) is a serious bacterial infection that must be treated efficiently and timely. The large number of culture-negative cases makes local epidemiological data important. Accordingly, this study aimed to evaluate the etiology, clinical characteristics, and therapeutic approach of SA in children in Turkiye, emphasizing the role of real-time polymerase chain reaction (PCR) techniques in the diagnosis. Methods: In this multi-center, prospective study, children hospitalized due to SA between February 2018 and July 2020 in 23 hospitals in 14 cities in Turkiye were included. Clinical, demographic, laboratory, and radiological findings were assessed, and real-time PCR was performed using synovial fluid samples. Results: Seventy-five children aged between 3 and 204 months diagnosed with acute SA were enrolled. Joint pain was the main complaint at admission, and the most commonly involved joints were the knees in 58 patients (77.4%). The combination of synovial fluid culture and real-time PCR detected causative bacteria in 33 patients (44%). In 14 (18.7%) patients, the etiological agent was demonstrated using only PCR. The most commonly isolated etiologic agent was Staphylococcus aureus , which was detected in 22 (29.3%) patients, while Streptococcus pyogenes was found in 4 (5.3%) patients and Kingella kingae in 3 (4%) patients. Streptococcus pyogenes and Kingella kingae were detected using only PCR. Most patients (81.3%) received combination therapy with multiple agents, and the most commonly used combination was glycopeptides plus third-generation cephalosporin. Conclusions: Staphylococcus aureus is the main pathogen in pediatric SA, and with the use of advanced diagnostic approaches, such as real-time PCR, the chance of diagnosis increases, especially in cases due to Kingella kingae and Streptococcus pyogenes.
Databáze:	MEDLINE
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