Platelet-Rich Plasma (PRP) in Dermatology: Cellular and Molecular Mechanisms of Action.

Autor:	Vladulescu D; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Dermatology I, Colentina Hospital, 020125 Bucharest, Romania., Scurtu LG; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Dermatology I, Colentina Hospital, 020125 Bucharest, Romania., Simionescu AA; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, 011132 Bucharest, Romania., Scurtu F; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, 011132 Bucharest, Romania., Popescu MI; Faculty of Medicine, 'Titu Maiorescu' University, 040441 Bucharest, Romania., Simionescu O; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Dermatology I, Colentina Hospital, 020125 Bucharest, Romania.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2023 Dec 19; Vol. 12 (1). Date of Electronic Publication: 2023 Dec 19.
DOI:	10.3390/biomedicines12010007
Abstrakt:	Platelet-rich plasma (PRP) therapy has gained attention in the scientific field due to its potential regenerative effects and great benefit-risk ratio. This review extensively explores the most studied mechanisms of this therapy according to the etiopathogenesis of skin diseases: cellular proliferation, matrix formation, regulation of inflammation, angiogenesis, collagen synthesis, and the remodeling of new tissue. Moreover, it draws on newly reported and lesser-known effects of PRP: its anti-apoptotic effects, immunological suppression, decrease in melanin synthesis, anti-microbial effects, overexpression of miR-155, antioxidant effects, and their involved pathways. This work aims to provide a complete update for understanding PRP's benefits and clinical relevance in wound healing, alopecia, pigmentary disorders, scars, rejuvenation, lichen sclerosus, and other inflammatory dermatoses, based on the current evidence. Furthermore, recent reports with novel indications for PRP therapy are highlighted, and new potential pathways correlated with the pathogenesis of skin diseases are explored. Competing Interests: The authors declare no conflicts of interest.
Databáze:	MEDLINE
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