Tempo and mode of gene expression evolution in the brain across primates.

Autor:	Rickelton K; Department of Biology, University of Massachusetts Amherst, Amherst, United States.; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, United States., Zintel TM; Department of Biology, University of Massachusetts Amherst, Amherst, United States.; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, United States., Pizzollo J; Department of Biology, University of Massachusetts Amherst, Amherst, United States.; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, United States., Miller E; Department of Biology, University of Massachusetts Amherst, Amherst, United States., Ely JJ; Department of Anthropology and Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, United States.; MAEBIOS Epidemiology Unit, Alamogordo, United States., Raghanti MA; Department of Anthropology, School of Biomedical Sciences, and Brain Health Research Institute, Kent State University, Kent, United States., Hopkins WD; Department of Comparative Medicine, Michale E. Keeling Center for Comparative Medicine,The University of Texas M D Anderson Cancer Centre, Bastrop, United States., Hof PR; New York Consortium in Evolutionary Primatology, New York, United States.; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States., Sherwood CC; Department of Anthropology and Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, United States., Bauernfeind AL; Department of Neuroscience, Washington University School of Medicine, St. Louis, United States.; Department of Anthropology, Washington University in St. Louis, St. Louis, United States., Babbitt CC; Department of Biology, University of Massachusetts Amherst, Amherst, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2024 Jan 26; Vol. 13. Date of Electronic Publication: 2024 Jan 26.
DOI:	10.7554/eLife.70276
Abstrakt:	Primate evolution has led to a remarkable diversity of behavioral specializations and pronounced brain size variation among species (Barton, 2012; DeCasien and Higham, 2019; Powell et al., 2017). Gene expression provides a promising opportunity for studying the molecular basis of brain evolution, but it has been explored in very few primate species to date (e.g. Khaitovich et al., 2005; Khrameeva et al., 2020; Ma et al., 2022; Somel et al., 2009). To understand the landscape of gene expression evolution across the primate lineage, we generated and analyzed RNA-seq data from four brain regions in an unprecedented eighteen species. Here, we show a remarkable level of variation in gene expression among hominid species, including humans and chimpanzees, despite their relatively recent divergence time from other primates. We found that individual genes display a wide range of expression dynamics across evolutionary time reflective of the diverse selection pressures acting on genes within primate brain tissue. Using our samples that represent a 190-fold difference in primate brain size, we identified genes with variation in expression most correlated with brain size. Our study extensively broadens the phylogenetic context of what is known about the molecular evolution of the brain across primates and identifies novel candidate genes for the study of genetic regulation of brain evolution. Competing Interests: KR, TZ, JP, EM, JE, MR, WH, PH, CS, AB, CB No competing interests declared (© 2024, Rickelton et al.)
Databáze:	MEDLINE
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