Lipids as mediators of cancer progression and metastasis.

Autor: Vogel FCE; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Chaves-Filho AB; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Institute of Chemistry, University of São Paulo, São Paulo, Brazil., Schulze A; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany. almut.schulze@dkfz-heidelberg.de.
Jazyk: angličtina
Zdroj: Nature cancer [Nat Cancer] 2024 Jan; Vol. 5 (1), pp. 16-29. Date of Electronic Publication: 2024 Jan 25.
DOI: 10.1038/s43018-023-00702-z
Abstrakt: Metastasis formation is a complex process, involving multiple crucial steps, which are controlled by different regulatory mechanisms. In this context, the contribution of cancer metabolism to the metastatic cascade is being increasingly recognized. This Review focuses on changes in lipid metabolism that contribute to metastasis formation in solid tumors. We discuss the molecular mechanisms by which lipids induce a pro-metastatic phenotype and explore the role of lipids in response to oxidative stress and as signaling molecules. Finally, we reflect on potential avenues to target lipid metabolism to improve the treatment of metastatic cancers.
(© 2024. Springer Nature America, Inc.)
Databáze: MEDLINE
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