Voriconazole-induced periostitis in a patient with HIV treated for coccidioidomycosis meningitis.
| Autor: | Nguyen QP; School of Medicine, University of California San Diego, La Jolla, California, USA q9nguyen@health.ucsd.edu., Wooten D; Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, California, USA. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | BMJ case reports [BMJ Case Rep] 2024 Jan 25; Vol. 17 (1). Date of Electronic Publication: 2024 Jan 25. |
| DOI: | 10.1136/bcr-2023-257884 |
| Abstrakt: | Voriconazole-induced periostitis is a rare adverse effect in patients on long-term therapy, characterised by periosteal inflammation and associated bony pain. The accompanying lab abnormalities (elevated serum alkaline phosphatase and fluoride) and characteristic imaging findings (uptake of radionuclide tracer on nuclear bone scan) are critical for diagnosis. The disease process is thought to be secondary to excess fluoride from voriconazole which stimulates bone formation and decreases osteoclast bone resorption. Management includes stopping voriconazole and switching to another agent. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|