Cytisine: State of the art in pharmacological activities and pharmacokinetics.

Autor: Wang X; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China., Yang J; Research Center for Infectious Diseases, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China., Huang P; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China., Wang D; The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China., Zhang Z; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China., Zhou Z; Research Center for Infectious Diseases, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China., Liang L; Research Center for Infectious Diseases, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address: lianglei7@tjutcm.edu.cn., Yao R; Research Center for Infectious Diseases, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address: yaorm20200101@tjutcm.edu.cn., Yang L; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Research Center for Infectious Diseases, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; School of Public Health, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address: long.yang@tjutcm.edu.cn.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Feb; Vol. 171, pp. 116210. Date of Electronic Publication: 2024 Jan 24.
DOI: 10.1016/j.biopha.2024.116210
Abstrakt: Cytisine is a naturally occurring bioactive compound, an alkaloid mainly isolated from legume plants. In recent years, various biological activities of cytisine have been explored, showing certain effects in smoking cessation, reducing drinking behavior, anti-tumor, cardiovascular protection, blood sugar regulation, neuroprotection, osteoporosis prevention and treatment, etc. At the same time, cytisine has the advantages of high efficiency, safety, and low cost, has broad development prospects, and is a drug of great application value. However, a summary of cytisine's biological activities is currently lacking. Therefore, this paper summarizes the pharmacological action, mechanism, and pharmacokinetics of cytisine by referring to numerous databases, and analyzes the new and core targets of cytisine with the help of computer simulation technology, to provide reference for doctors.
Competing Interests: Declaration of Competing Interest All authors declare that No conflict of interest exists.
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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