Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein.

Autor: McMillan CLD; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, Queensland 4072 and 4029, Australia., Wijesundara DK; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.; Vaxxas Biomedical Facility, Hamilton, Queensland 4007, Australia., Choo JJY; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia., Amarilla AA; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia., Modhiran N; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia., Fernando GJP; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.; Vaxxas Biomedical Facility, Hamilton, Queensland 4007, Australia., Khromykh AA; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, Queensland 4072 and 4029, Australia., Watterson D; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, Queensland 4072 and 4029, Australia., Young PR; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, Queensland 4072 and 4029, Australia., Muller DA; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, Queensland 4072 and 4029, Australia.
Jazyk: angličtina
Zdroj: The Journal of general virology [J Gen Virol] 2024 Jan; Vol. 105 (1).
DOI: 10.1099/jgv.0.001947
Abstrakt: The COVID-19 pandemic has highlighted the need for vaccines capable of providing rapid and robust protection. One way to improve vaccine efficacy is delivery via microarray patches, such as the Vaxxas high-density microarray patch (HD-MAP). We have previously demonstrated that delivery of a SARS-CoV-2 protein vaccine candidate, HexaPro, via the HD-MAP induces potent humoral immune responses. Here, we investigate the cellular responses induced by HexaPro HD-MAP vaccination. We found that delivery via the HD-MAP induces a type one biassed cellular response of much greater magnitude as compared to standard intramuscular immunization.
Databáze: MEDLINE
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