Only anti-GM4 antibody positivity in a Chinese girl with overlapping MFS/GBS: a case report.

Autor:	Chen J; Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, No. 143, Dalian Road, Zunyi, 563003, China., Tian M; Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, No. 143, Dalian Road, Zunyi, 563003, China., Shu X; Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, No. 143, Dalian Road, Zunyi, 563003, China. Shuxiaomei1993@sina.com.
Jazyk:	angličtina
Zdroj:	Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2024 May; Vol. 45 (5), pp. 2331-2335. Date of Electronic Publication: 2024 Jan 25.
DOI:	10.1007/s10072-024-07300-6
Abstrakt:	Background: Guillain-Barré syndrome (GBS), as the most common cause of acute flaccid paralysis worldwide, is considered a part of a clinical spectrum in which discrete, complete, or incomplete forms of GBS and overlapping syndromes lie on the basis of their clinical features. The term overlapping Miller Fisher syndrome (MFS)/GBS is used when patients with MFS also suffer from progressive motor weakness of the limbs. Anti-ganglioside GQ1b has been specifically associated with MFS and ophthalmoplegia. Case Description: Here, we report a Chinese girl who was diagnosed with overlapping MFS/GBS showing acute flaccid paralysis of all four limbs, sensory symptoms, cranial nerve dysfunction, autonomic involvement, ophthalmoplegia, and ataxia. She had high serum and cerebrospinal fluid titres of monospecific anti-GM4 IgG antibody instead of anti-GQ1b antibody in the acute phase. Conclusion: Anti-GM4 antibodies usually coexist with other antiganglioside antibodies, leading to missed diagnoses. The findings of the present study show that antibodies to ganglioside GM4 may in overlapping MFS/GBS as the lone immunological factors. (© 2024. The Author(s).)
Databáze:	MEDLINE
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