Assessment of Tp-Te interval in patients with cardiac AL amyloidosis.

Autor:	Tor YB; Department of Internal Medicine, Memorial Bahcelievler Hospital, Istanbul, Turkey. Email: yavuzburaktor@gmail.com., Habibov I; Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey., Altinkaynak M; Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey., Aydogan M; Department of Cardiology, Bitlis Tatvan State Hospital, Bitlis, Turkey., Baykiz D; Department of Cardiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey., Tayfur M; Department of Internal Medicine, Health Sciences University, Umraniye Training and Research Hospital, Istanbul, Turkey., Gonenli MG; Department of Internal Medicine, Koc University School of Medicine, Istanbul, Turkey., Onur I; Department of Internal Medicine, Memorial Bahcelievler Hospital, Istanbul, Turkey., Kalayoglu-Besisik S; Division of Haematology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey., Saka B; Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey., Erten SN; Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey., Akpinar TS; Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Cardiovascular journal of Africa [Cardiovasc J Afr] 2024 Jan 15; Vol. 34, pp. 1-5. Date of Electronic Publication: 2024 Jan 15.
DOI:	10.5830/CVJA-2023-059
Abstrakt:	Background: Prolonged Tp-Te interval is strongly associated with fatal ventricular arrhythmias and mortality. This association has been demonstrated in various diseases. However, the current literature does not give any information on Tp-Te interval in cardiac amyloid light-chain (AL) amyloidosis. Methods: We retrospectively screened 116 cardiac AL amyloidosis patients and 35 patients were included in the study. Demographic, laboratory, 12-lead electrocardiographic (QTc, Tp-Te V1-V6) and transthoracic echocardiographic data of the patients were analysed and compared with 35 healthy controls. Results: QTc and Tp-Te V2-V5 were significantly prolonged in the cardiac AL amyloidosis group ( p < 0.05). Also, there was a positive and statistically significant correlation between the parameters of QTc and Tp-Te V3-V6, and also between the parameters of interventricular septum thickness at enddiastole and Tp-Te V2-V5. Conclusion: We present the first strong evidence of prolonged Tp-Te intervals in patients with cardiac AL amyloidosis. There may also be a relationship between prolonged Tp-Te interval and the development of arrhythmia in this patient group, as in some other groups. There is a need for prospective studies examining the relationship of prolonged Tp-Te interval with arrhythmias and its prognostic significance in cardiac AL amyloidosis.
Databáze:	MEDLINE
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