Endogenous origin of Pseudomonas aeruginosa infecting hospitalized patients in Ecuador.

Autor:	Vasco G; Instituto de Microbiología, Universidad San Francisco de Quito USFQ, Quito, Ecuador.; Escuela de Medicina, Facultad de Ciencias Médicas, Universidad Central del Ecuador, Quito, Ecuador., Achig M; Escuela de Medicina, Facultad de Ciencias Médicas, Universidad Central del Ecuador, Quito, Ecuador., Prado-Vivar B; Instituto de Microbiología, Universidad San Francisco de Quito USFQ, Quito, Ecuador.; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3052, Australia., Páez M; Laboratorio Clínico-Microbiología Hospital General Docente de Calderón, Quito, Ecuador., Espinosa F; Laboratorio Clínico, Hospital 'Padre Carollo Un Canto Para la Vida', Quito, Ecuador., Espinoza E; Laboratorio Clínico-Microbiología Hospital General Docente de Calderón, Quito, Ecuador., Quinancela D; Escuela de Medicina, Facultad de Ciencias Médicas, Universidad Central del Ecuador, Quito, Ecuador., Cardenas P; Instituto de Microbiología, Universidad San Francisco de Quito USFQ, Quito, Ecuador., Trueba G; Instituto de Microbiología, Universidad San Francisco de Quito USFQ, Quito, Ecuador.
Jazyk:	angličtina
Zdroj:	Infection prevention in practice [Infect Prev Pract] 2023 Dec 11; Vol. 6 (1), pp. 100331. Date of Electronic Publication: 2023 Dec 11 (Print Publication: 2024).
DOI:	10.1016/j.infpip.2023.100331
Abstrakt:	Recent evidence suggests that Pseudomonas aeruginosa , a bacterium that has the ability to cause deadly infections in hospitalized patients, could originate in the patient's own flora. We employed the Oxford Nanopore platform to obtain whole genome sequences (WGS) from clinical and rectal screen P. aeruginosa strains belonging to 15 patients from two hospitals. Our study found evidence that clinical and rectal isolates were clonal, with some evidence suggesting that the infecting strain was present in the patient's intestine at the time of admission, ruling out hospital acquisition. The use of WGS analysis is crucial to detect alternative sources of P . aeruginosa to develop new preventive measures against these serious infections. (© 2023 The Authors.)
Databáze:	MEDLINE
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