Increased Peripheral Blood DNA Damage and Elevated Serum Levels of Melanoma Inhibitory Activity Protein: Clues to Excess Skin Cancer Risk in Airline Pilots?

Autor:	Minoretti P; General Direction, Studio Minoretti, Oggiono, ITA., Liaño Riera M; Legal Medicine, Psychiatry, and Pathology, Complutense University of Madrid, Madrid, ESP., Santiago Sáez A; Legal Medicine, Hospital Clinico San Carlos, Madrid, ESP.; Legal Medicine, Psychiatry, and Pathology, Complutense University of Madrid, Madrid, ESP., Gómez Serrano M; Legal Medicine, Psychiatry, and Pathology, Complutense University of Madrid, Madrid, ESP., García Martín Á; Legal Medicine, Psychiatry, and Pathology, Complutense University of Madrid, Madrid, ESP.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Dec 25; Vol. 15 (12), pp. e51077. Date of Electronic Publication: 2023 Dec 25 (Print Publication: 2023).
DOI:	10.7759/cureus.51077
Abstrakt:	Background and objective The risk of malignant melanoma (MM) and other forms of skin cancer appears to be higher in airline pilots (APs), potentially due to their exposure to ionizing and ultraviolet (UV) radiation. We explored the possibility of increased peripheral blood DNA damage and elevated serum levels of the melanoma inhibitory activity (MIA) protein - a serological marker for MM known to be stimulated by UV radiation - in this professional group. Methods This was a case-control study involving 40 male APs, each of whom was age- and tenure-matched (≥5 years of service) with 40 male office workers (OWs). We assessed DNA damage in the two professional groups by performing comet and micronucleus (MN) assays on peripheral blood. Serum levels of MIA protein were quantified using an immunoassay. Results The comet tail lengths and the frequency of MN were significantly higher in APs (4.57 ± 0.79 µm and 2.05 ± 0.26 per 1000 cells, respectively) than in OWs (3.81 ± 0.60 µm and 1.76 ± 0.31 per 1000 cells, respectively, both p<0.001). Furthermore, serum MIA levels were also significantly higher in APs (7.45 ± 0.95 ng/mL) than in OWs (5.78 ± 0.54 ng/mL, p<0.001). A significant positive correlation was found between comet tail lengths in APs and their serum MIA concentrations (r=0.68, p<0.01). Conclusions The increased burden of DNA damage and elevated serum MIA levels in APs may offer an explanation for their higher susceptibility to MM and other types of skin cancers. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Minoretti et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu