Chronic Drug-Induced Liver Injury from Labetalol during the Postpartum Period: A Case Report.
| Autor: | Lee B; Department of Obstetrics and Gynecology, Rochester General Hospital, Rochester, New York., Xiong S; Department of Pharmaceutical Care - Ambulatory Care, Digestive Health Center, University of Iowa Hospitals & Clinics, Coralville, Iowa., Westen EA; Department of Maternal-Fetal Medicine, Rochester General Hospital, Rochester, New York., Warner JA; Department of Pathology and Laboratory Medicine, Rochester General Hospital, Rochester, New York. |
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| Jazyk: | angličtina |
| Zdroj: | AJP reports [AJP Rep] 2024 Jan 23; Vol. 14 (1), pp. e43-e47. Date of Electronic Publication: 2024 Jan 23 (Print Publication: 2024). |
| DOI: | 10.1055/a-2209-4636 |
| Abstrakt: | Drug-induced liver injury (DILI) is a common cause of transaminitis in pregnancy. A 34-year-old G3P2012 presented 3 weeks postpartum for preeclampsia with severe features. After receiving acute antihypertensive medications, she was discharged home with labetalol. She presented 5 months later with general malaise, scleral icterus, nausea, and mild right upper quadrant pain and found to have significantly elevated transaminitis. She had a negative infectious, autoimmune, biliary, and steatohepatitis workup. A liver biopsy was performed supporting the diagnosis of DILI. After patient self-discontinued labetalol, her hepatitis significantly improved. However, she developed chronic DILI and liver enzymes normalized during her subsequent pregnancy at 34 weeks. Patient's written consent was obtained for this case report. Chronic DILI secondary to labetalol use is a rare and potentially fatal condition that should be considered on the differential for transaminitis during pregnancy and postpartum period. Competing Interests: Conflict of Interest None declared. (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).) |
| Databáze: | MEDLINE |
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