Reviving peritoneal cytology: Exploring its role in endometrial cancer molecular classification.

Autor: Villiger AS; Department of Obstetrics and Gynecology, Bern University Hospital and University of Bern, Bern, Switzerland., Zurbriggen S; University of Bern, Bern, Switzerland., Imboden S; Department of Obstetrics and Gynecology, Bern University Hospital and University of Bern, Bern, Switzerland., Solass W; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland., Christe L; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland., Saner FAM; Department of Obstetrics and Gynecology, Bern University Hospital and University of Bern, Bern, Switzerland., Gmür A; Department of Obstetrics and Gynecology, Bern University Hospital and University of Bern, Bern, Switzerland., Rau TT; Institute of Pathology, Universitätsklinikum Düsseldorf, Düsseldorf, Germany., Mueller MD; Department of Obstetrics and Gynecology, Bern University Hospital and University of Bern, Bern, Switzerland., Siegenthaler F; Department of Obstetrics and Gynecology, Bern University Hospital and University of Bern, Bern, Switzerland. Electronic address: Franziska.siegenthaler@insel.ch.
Jazyk: angličtina
Zdroj: Gynecologic oncology [Gynecol Oncol] 2024 Mar; Vol. 182, pp. 148-155. Date of Electronic Publication: 2024 Jan 23.
DOI: 10.1016/j.ygyno.2024.01.006
Abstrakt: Objective: The prognostic significance of positive peritoneal cytology in endometrial cancer has long been debated. In 2009, the Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) removed cytology as a staging criterion from the endometrial cancer staging system. However, there is still evidence that positive peritoneal cytology may decrease survival among patients with endometrial cancer. The aim of this study was to determine the prognostic significance of positive peritoneal cytology among the different molecular subgroups.
Methods: This study included patients with endometrial cancer who underwent primary surgical treatment between 2004 and 2015 at the Bern University Hospital, Switzerland, with molecular classification of the primary tumor and peritoneal cytology performed.
Results: A total, 250 patients with endometrial cancer were enrolled. Peritoneal cytology was assessed in 206 patients, of whom 24% were positive: 25% of the POLEmut, 16% of the MMRd, 41% of the p53abn, and 24% of the NSMP cases. The mean follow-up was 128.7 months. Presence of positive peritoneal cytology was associated with significantly decreased mean recurrence-free and overall survival in patients with p53abn (p = .003 and p = .001) and NSMP (p = .020 and p = .049) endometrial cancer. In multivariable Cox regression analysis, positive peritoneal cytology remained an independent predictor of recurrence (p = .033) and death (p = .008) in p53abn endometrial cancer patients.
Conclusion: Positive peritoneal cytology is associated with worse oncologic outcomes in NSMP and p53abn endometrial cancer and remains an independent predictor of recurrence and death in patients with p53abn endometrial cancer.
Competing Interests: Declaration of competing interest All authors declare no conflict of interest.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE