In situ generation of copper(Ⅱ)/diethyldithiocarbamate complex through tannic acid/copper(Ⅱ) network coated hollow mesoporous silica for enhanced cancer chemodynamic therapy.

Autor: Zhu Y; School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, PR China., Wang N; School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, PR China., Ling J; School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, PR China., Yang L; School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, PR China., Omer AM; Polymer Materials Research Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P. O. Box: 21934, Alexandria, Egypt., Ouyang XK; School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, PR China. Electronic address: xkouyang@zjou.edu.cn., Yang G; Department of Cardiothoracic Surgery, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316000, PR China. Electronic address: hydygc@163.com.
Jazyk: angličtina
Zdroj: Journal of colloid and interface science [J Colloid Interface Sci] 2024 Apr 15; Vol. 660, pp. 637-646. Date of Electronic Publication: 2024 Jan 20.
DOI: 10.1016/j.jcis.2024.01.121
Abstrakt: The Cu 2+ complex formed by the coordination of disulfiram (DSF) metabolite diethyldithiocarbamate (DTC), Cu(DTC) 2 , can effectively inhibit tumor growth. However, insufficient Cu 2+ levels in the tumor microenvironment can impact tumor-suppressive effects of DTC. In this study, we proposed a Cu 2+ and DSF tumor microenvironment-targeted delivery system. This system utilizes hollow mesoporous silica (HMSN) as a carrier, after loading with DSF, encases it using a complex of tannic acid (TA) and Cu 2+ on the outer layer. In the slightly acidic tumor microenvironment, TA/Cu undergoes hydrolysis, releasing Cu 2+ and DSF, which further form Cu(DTC) 2 to inhibit tumor growth. Additionally, Cu 2+ can engage in a Fenton-like reaction with H 2 O 2 in the tumor microenvironment to form OH, therefore, chemodynamic therapy (CDT) and Cu(DTC) 2 are used in combination for tumor therapy. In vivo tumor treatment results demonstrated that AHD@TA/Cu could accumulate at the tumor site, achieving a tumor inhibition rate of up to 77.6 %. This study offers a novel approach, circumventing the use of traditional chemotherapy drugs, and provides valuable insights into the development of in situ tumor drug therapies.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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