Air pollution is associated with increased incidence-rate of head and neck cancers: A nationally representative ecological study.

Autor: Ochoa Scussiatto H; Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, IL, USA; Section of Otolaryngology-Head and Neck Surgery, The University of Chicago, Chicago, IL, USA., Stenson KM; Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, IL, USA., Al-Khudari S; Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, IL, USA., Jelinek MJ; Department of Medical Oncology, Rush University Medical Center, Chicago, IL, USA., Pinto JM; Section of Otolaryngology-Head and Neck Surgery, The University of Chicago, Chicago, IL, USA., Bhayani MK; Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, IL, USA. Electronic address: Mihir_Bhayani@rush.edu.
Jazyk: angličtina
Zdroj: Oral oncology [Oral Oncol] 2024 Mar; Vol. 150, pp. 106691. Date of Electronic Publication: 2024 Jan 23.
DOI: 10.1016/j.oraloncology.2024.106691
Abstrakt: Introduction: Early studies show conflicting findings regarding particulate matter ≤ 2.5 μm in diameter (PM 2.5 ) exposure and development of head and neck cancers (HNC). We analyzed the relationship between PM 2.5 exposure and various types of HNC in a nationally representative ecological sample.
Methods: We determined HNC incidence in 608 US counties from 2011 to 2019 using the Surveillance, Epidemiology and End Results (SEER) Program from the National Cancer Institute. We also collected information on sociodemographic factors from SEER and data on smoking and alcohol intake from CDC data frames (county level). PM 2.5 exposure levels were estimated using satellite and meteorological data via previously validated general additive models. Flexible semi-nonparametric regression models were used to test the relationship between PM 2.5 exposure levels and HNC incidence, adjusting for demographics, socioeconomic factors, and comorbidity.
Results: Increased PM 2.5 exposure levels were associated with higher incidence-rates of oral cavity and pharyngeal cancers controlling for confounders in our primary analyses (IRR = 1.04, 95 % CI 1.01, 1.07, p = 0.02 per 1 μg/m 3 increase in PM 2.5 ). This relationship was maintained after adjusting for multiple testing (Holm s method, p = 0.04) and in ordinary least squares (OLS) regression (β = 0.17, 95 % CI 0.01, 0.57, p = 0.01). Increased exposure was also associated with other HNC: esophagus (IRR = 1.06, 95 % CI 1.01, 1.11, p = 0.02), lip (IRR = 1.16, 95 % CI 1.03, 1.31, p = 0.01), tonsil (IRR = 1.10, 95 % CI 1.03, 1.16, p < 0.01). However, these relationships were not maintained in secondary analyses.
Conclusions: This nationally representative ecological study shows that increased levels of air pollution are associated with increased incidence of overall oral cavity and pharyngeal cancers in the US.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: