Changes in prospectively collected patient-reported outcomes among women with incident endometrial cancer.

Autor: Sinnott JA; Department of Statistics, The Ohio State University College of Arts and Sciences, Columbus, OH, USA., Torkashvand E; Division of Epidemiology, The Ohio State University College of Public Health, 1841 Neil Avenue, 304 Cunz Hall, Columbus, OH, 43210, USA., Meade CE; Division of Epidemiology, The Ohio State University College of Public Health, 1841 Neil Avenue, 304 Cunz Hall, Columbus, OH, 43210, USA., Salani R; Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA, USA., Vetter MH; Division of Gynecologic Oncology, Baptist Health Medicine Group, Lexington, KY, USA., Hall B; Division of Epidemiology, The Ohio State University College of Public Health, 1841 Neil Avenue, 304 Cunz Hall, Columbus, OH, 43210, USA., Skolnick R; Denison University, Granville, OH, USA., Bixel KL; Division of Gynecologic Oncology, The Ohio State University College of Medicine, Columbus, OH, USA., Cohn DE; Division of Gynecologic Oncology, The Ohio State University College of Medicine, Columbus, OH, USA., Cosgrove CM; Division of Gynecologic Oncology, The Ohio State University College of Medicine, Columbus, OH, USA., Copeland LJ; Division of Gynecologic Oncology, The Ohio State University College of Medicine, Columbus, OH, USA., Hebert C; Division of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH, USA., Felix AS; Division of Epidemiology, The Ohio State University College of Public Health, 1841 Neil Avenue, 304 Cunz Hall, Columbus, OH, 43210, USA. Felix.20@osu.edu.
Jazyk: angličtina
Zdroj: Journal of cancer survivorship : research and practice [J Cancer Surviv] 2024 Jan 24. Date of Electronic Publication: 2024 Jan 24.
DOI: 10.1007/s11764-024-01536-z
Abstrakt: Purpose: We examined associations between patient and treatment characteristics with longitudinally collected patient-reported outcome (PRO) measures to provide a data-informed description of the experiences of women undergoing treatment for endometrial cancer.
Methods: We administered National Institutes of Health Patient Reported Outcomes Measurement Information System (PROMIS) questionnaires at the preoperative visit and at 6 and 12 months after surgery. Anxiety, depression, fatigue, sleep disturbance, pain, physical function, and ability to participate in social roles were assessed. Analysis of variance (ANOVA) and linear mixed models were used to examine associations between patient characteristics and PRO measures at baseline and through time.
Results: Of 187 women enrolled, 174 (93%) and 103 (69%) completed the 6- and 12-month questionnaires, respectively. Anxiety was substantially elevated at baseline (half of one population-level standard deviation) and returned to general population mean levels at 6 and 12 months. Younger age, Medicaid/None/Self-pay insurance, prevalent diabetes, and current smoking were associated with higher symptom burden on multiple PRO measures across the three time points. Women with aggressive histology, higher disease stage, or those with adjuvant treatment had worse fatigue at 6 months, which normalized by 12 months.
Conclusions: We observed a high symptom burden at endometrial cancer diagnosis, with most PRO measures returning to general population means by 1 year. Information on risk factor-PRO associations can be used during the clinical visit to inform supportive service referral.
Implications for Cancer Survivors: These findings can inform clinicians' discussions with endometrial cancer survivors regarding expected symptom trajectory following diagnosis and treatment.
(© 2024. The Author(s).)
Databáze: MEDLINE
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