The tongue microbiome of young patients with chronic kidney disease and their healthy mothers.

Autor: Hoefer KC; University of Cologne, Faculty of Medicine and University Hospital Cologne, Polyclinic for Operative Dentistry and Periodontology, Cologne, Germany. karolin.hoefer@uk-koeln.de., Weber LT; Children´s and Adolescents Hospital, Pediatric Nephrology, University Hospital of Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany., Barbe AG; University of Cologne, Faculty of Medicine and University Hospital Cologne, Polyclinic for Operative Dentistry and Periodontology, Cologne, Germany., Graf I; Department of Orthodontics, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany., Thom S; Wisplinghoff Laboratories, Cologne, Germany., Nowag A; Wisplinghoff Laboratories, Cologne, Germany., Scholz CJ; Wisplinghoff Laboratories, Cologne, Germany., Wisplinghoff H; Wisplinghoff Laboratories, Cologne, Germany.; Institute for Virology and Microbiology, Witten/Herdecke University, Witten, Germany., Noack MJ; University of Cologne, Faculty of Medicine and University Hospital Cologne, Polyclinic for Operative Dentistry and Periodontology, Cologne, Germany., Jazmati N; Wisplinghoff Laboratories, Cologne, Germany.; Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2024 Jan 24; Vol. 28 (1), pp. 110. Date of Electronic Publication: 2024 Jan 24.
DOI: 10.1007/s00784-024-05492-x
Abstrakt: Objectives: Oral microbiome plays a crucial role in the incidence and development of oral diseases. An altered intestinal microbiome has been reported in adults with chronic kidney disease (CKD). This study aimed to characterize the tongue microbiome of young patients with CKD compared to their healthy mothers to identify the influence of CKD-associated factors on resilient tongue ecosystem.
Material and Methods: Thirty patients with CKD (mean age, 14.2 years; 16 males and 14 females) and generalized gingivitis were included in the study. Swabs of the posterior tongue were collected from the patients and 21 mothers (mean age 40.8 years). Next-generation sequencing of 16S rDNA genes was employed to quantitatively characterize microbial communities.
Results: The bacterial communities were similar in terms of richness and diversity between patients and mothers (p > 0.05). In patients with CKD, 5 core phyla, 20 core genera, and 12 core species were identified.
Conclusions: The tongue microbiome of the study participants showed no relevant CKD-associated differences compared to their mothers and appears to be a highly preserved niche in the oral cavity. Differences observed in the abundance of individual species in this study could be attributed to the age rather than CKD, even after a mean disease duration of 11 years.
Clinical Relevance: CKD and its associated metabolic changes appear to have no detectable impact on the resilient tongue microbiome observed in young patients.
(© 2024. The Author(s).)
Databáze: MEDLINE
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