The impact of a tDCS and cognitive training intervention on task-based functional connectivity.

Autor: Kraft JN; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA.; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA., Indahlastari A; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Boutzoukas EM; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Hausman HK; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Hardcastle C; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Albizu A; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA.; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA., O'Shea A; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Evangelista ND; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Van Etten EJ; Brain Imaging, Behavior and Aging Laboratory, Department of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA., Bharadwaj PK; Brain Imaging, Behavior and Aging Laboratory, Department of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA., Song H; Brain Imaging, Behavior and Aging Laboratory, Department of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA., Smith SG; Brain Imaging, Behavior and Aging Laboratory, Department of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA., DeKosky ST; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA.; McKnight Brain Institute and Department of Neurology, University of Florida, Gainesville, FL, USA., Hishaw GA; Department of Psychiatry, Neuroscience and Physiological Sciences Graduate Interdisciplinary Programs, and BIO5 Institute, University of Arizona and Arizona Alzheimer's Consortium, Tucson, AZ, USA., Wu S; Department of Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Marsiske M; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Cohen R; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Alexander GE; McKnight Brain Institute and Department of Neurology, University of Florida, Gainesville, FL, USA.; Department of Psychiatry, Neuroscience and Physiological Sciences Graduate Interdisciplinary Programs, and BIO5 Institute, University of Arizona and Arizona Alzheimer's Consortium, Tucson, AZ, USA., Porges E; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Woods AJ; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1249 Center Drive, Gainesville, FL, 32603, USA. ajwoods@phhp.ufl.edu.; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA. ajwoods@phhp.ufl.edu.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA. ajwoods@phhp.ufl.edu.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2024 Jun; Vol. 46 (3), pp. 3325-3339. Date of Electronic Publication: 2024 Jan 24.
DOI: 10.1007/s11357-024-01077-4
Abstrakt: Declines in several cognitive domains, most notably processing speed, occur in non-pathological aging. Given the exponential growth of the older adult population, declines in cognition serve as a significant public health issue that must be addressed. Promising studies have shown that cognitive training in older adults, particularly using the useful field of view (UFOV) paradigm, can improve cognition with moderate to large effect sizes. Additionally, meta-analyses have found that transcranial direct current stimulation (tDCS), a non-invasive form of brain stimulation, can improve cognition in attention/processing speed and working memory. However, only a handful of studies have looked at concomitant tDCS and cognitive training, usually with short interventions and small sample sizes. The current study assessed the effect of a tDCS (active versus sham) and a 3-month cognitive training intervention on task-based functional connectivity during completion of the UFOV task in a large older adult sample (N = 153). We found significant increased functional connectivity between the left and right pars triangularis (the ROIs closest to the electrodes) following active, but not sham tDCS. Additionally, we see trending behavioral improvements associated with these functional connectivity changes in the active tDCS group, but not sham. Collectively, these findings suggest that tDCS and cognitive training can be an effective modulator of task-based functional connectivity above and beyond a cognitive training intervention alone.
(© 2024. The Author(s), under exclusive licence to American Aging Association.)
Databáze: MEDLINE
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